Construction of polymeric micelle with thermo-responsive poly(amino acid)s

2017 Fiscal Year Final Research Report

• Project/Area Number: 16H07494
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
• Principal Investigator: Hayashi Kotaro 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (00780660)
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: バイオマテリアル / 機能性高分子

Outline of Final Research Achievements

Although antisense oligonucleotides, which selectively suppress genes overexpressed in intractable diseases, have been expected as next molecular targeting drugs, therapeutic use of them was limited due to poor accumulation into target tissues or cells. Delivery system of them has been researched to overcome the hurdle. Herein, I synthesized poly(amino acid) based thermo-responsible polymer for polymeric nanomicelles, directing to stabilization of nanoparticles by additional protective layer under intravital circumstance. Synthesized poly(amino acid) polymer exhibited phase transition around 25 degree. This polymer was expected as biocompatible materials for highly-functionalized delivery carrier design for effective accumulation into target tissues.

Free Research Field

科学