2017 Fiscal Year Final Research Report
Analysis of a regulatory mechanism of directional migration of endothelial tip cells during angiogenesis by bioimaging
| Project/Area Number |
16H07499
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Wakayama Yuki 国立研究開発法人国立循環器病研究センター, 研究所, 流動研究員 (70782853)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Keywords | 血管新生 / VEGFR2 / ゼブラフィッシュ |
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| Outline of Final Research Achievements |
Angiogenesis is the process to form new blood vessels. In this study, I investigated the regulatory mechanism of endothelial cell migration by bioimaging technique. It is suggested that Vascular endothelial growth factor receptor 2 (VEGFR2) is transported by KIF13B, a molecular motor, to the leading edge in leader cells. And I found that cell adhesion is important for endothelial cell migration.
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| Free Research Field |
細胞生物学
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