Prevalence and transfer-lisk to humans of beta-lactamase-producing Enterobacteriaceae among companion animals.

2018 Fiscal Year Final Research Report

• Project/Area Number: 16H07501
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Hygiene and public health
• Research Institution: Osaka Institute of Public Health (2017-2018); Osaka City Institute of Public Health and Environmental Sciences (2016)
• Principal Investigator: Umeda Kaoru (中田薫) 地方独立行政法人 大阪健康安全基盤研究所, 微生物部, 主任研究員 (90332444)
• Research Collaborator: Matsuo Masashi ; Horimoto Tomoaki ; Hase Atsushi ; Fukuda Akira
• Project Period (FY): 2016-08-26 – 2018-03-31
• Keywords: 薬剤耐性菌 / βラクタマーゼ産生菌 / 伴侶動物 / ワンヘルス

Outline of Final Research Achievements

We investigated the prevalence of cephalosporin-resistant Enterobacteriaceae among sheltered dogs and cats with various backgrounds. Cephalosporin-resistant Enterobacteriaceae was detected in 22 dogs (14.6%) and 20 cats (11.0%): 21 were extended-spectrum β-lactamase (ESBL)-producing, 20 were AmpC-producing, and 1 was both ESBL- and AmpC-producing. We found several types of cephalosporin-resistant Enterobacteriaceae distributed among companion animals with a range of individual attributes and histories in Osaka, Japan. Companion animals may play a bridging role in the circulation of antimicrobial-resistant bacteria from humans and from other origins.

Free Research Field

細菌学

Academic Significance and Societal Importance of the Research Achievements

ヒト・動物・環境を含めた薬剤耐性菌の蔓延が問題となっている。イヌ・ネコ等の伴侶動物はヒトと密接な関係を持ち、薬剤耐性菌が双方向に伝播しうるため、多様な生活背景を持つ収容動物の調査は耐性菌の汚染指標となりうる。本研究から多様な生活背景を持つイヌ・ネコが高率にβラクタマーゼ産生菌を保有し、その耐性遺伝子型にはヒトでの頻出型が含まれることが分かった。これはヒトと伴侶動物間での薬剤耐性菌の伝播や、ヒト・動物・環境における多様な薬剤耐性菌の蔓延を示唆するものである。