2016 Fiscal Year Annual Research Report
ピクセル型放射線検出器を用いた動的適応小線源治療システムの開発
| Project/Area Number |
16J04075
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| Research Institution | Kyushu University |
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Principal Investigator |
TRAN THI THAO NGUYEN 九州大学, 医学系学府, 特別研究員(DC1)
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| Project Period (FY) |
2016-04-22 – 2019-03-31
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| Keywords | Cervical cancer / Brachytherapy / Heterogeneous materials / Monte Carlo simulation / 3D gamma analysis |
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| Outline of Annual Research Achievements |
Our purpose is to develop a dynamic adaptive brachytherapy system for real-time visualization of four-dimensional in vivo locations of an applicator, 192Ir source, tumor, OAR, and dose distributions for intracavitary brachytherapy using a pixel-based portable radiation camera. For that purpose, at first, dosimetric impacts of heterogeneous materials on dose distributions for cervical cancer intracavitary brachytherapy have been investigated using Monte Carlo simulation. Second, we has designed the a pixel-based portable radiation camera using Monte Carlo simulations based on the Particle and Heavy Ion Transport (PHITS) code System, and an automated system for dynamic estimation of seed locations for cervical intracavitary brachytherapy.
The results of this research have been published in 2 international conference (American Association of Physics in Medicine; International Conference on Medical Physics) and 2 domestic conferences, in which the research could receive encouraging and constructive comments. In addition, the research has received the Best Oral Presentation Award of the 9th Vietnamese - Japanese Student’s Scientific Exchange Meeting (VJSE-2016). Furthermore, the research has been published in a journal in the field of radiation research (Journal of Radiation Research) in collaboration with researchers from Kagoshima University Hospital, Kagoshima, Japan.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
Our purpose is to develop a dynamic adaptive brachytherapy system for real-time visualization of four-dimensional in vivo locations of an applicator, 192Ir source, tumor, OAR, and dose distributions for intracavitary brachytherapy using a pixel-based portable radiation camera. For that purpose, at first, dosimetric impacts of heterogeneous materials on dose distributions for cervical cancer intracavitary brachytherapy have been investigated using Monte Carlo simulation. To evaluate the impacts of heterogeneous materials on dose distributions, the comparisons of water phantoms and patient physical maps, which were constructed by converting CT values in planning CT images, were performed on Monte Carlo-based dose distributions by using 3D gamma analysis. Second, we has designed the a pixel-based portable radiation camera using Monte Carlo simulations based on the Particle and Heavy Ion Transport (PHITS) code System, and an automated system for dynamic estimation of seed locations for cervical intracavitary brachytherapy. As a proof-of-concept study, a patient physical map based on planning CT image was employed in this study. 192Ir seed and gamma camera were positioned in the patient physical map.
The results of this research have been published in 2 international and 2 domestic conferences. In addition, the research has received the Best Oral Presentation Award of the VJSE-2016. Furthermore, the research has been published in Journal of Radiation Research in collaboration with researchers from Kagoshima University Hospital.
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| Strategy for Future Research Activity |
We will improve the automated system for dynamic estimation of seed locations based on a pixel-based portable radiation camera using Monte Carlo simulations based on the Particle and Heavy Ion Transport code System.
Next an automated recognition approach for the applicator, source, tumor, and OAR will be developed for the treatment of cervical cancer in intracavitary brachytherapy.
In addition, an estimation approach for planning computerized tomography images as well as magnetic resonance images during the treatment time using a 2D/3D image registration will be developed.
Finally, 4D dose distribution during the treatment time will be estimated.
The results will be presented in the international and domestic conferences and submitted to international journal.
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| Remarks |
Best Oral Presentation Award in VJSE-2016
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