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2018 Fiscal Year Annual Research Report

ピクセル型放射線検出器を用いた動的適応小線源治療システムの開発

Research Project

Project/Area Number 16J04075
Research InstitutionKyushu University

Principal Investigator

Tran Thi Thao Nguyen  九州大学, 医学系学府, 特別研究員(DC1)

Project Period (FY) 2016-04-22 – 2019-03-31
KeywordsCold spots / IMRT / VMAT / Prostate cancer
Outline of Annual Research Achievements

Small volumes of low dose regions (cold spots) in the target volume in prostate cancer treatment could cause recurrence of tumors. This study aimed to compare volumetric-modulated arc therapy (VMAT) with intensity-modulated radiation therapy (IMRT) accounting for cold spots in prostate cancer plans. The basic idea was to evaluate dosimetric indices for the planning target volume (PTV) and organs at risk (OAR), and analyze cold spots (numbers and volumes) of the PTV and the region in which the rectum overlapped with the PTV (ROP) region for VMAT and IMRT plans. Three-dimensional probabilistic distributions of cold spots were also generated using a centroid matching technique for visualization and analysis. The differences between the VMAT and IMRT plans were evaluated using two-sided paired Student’s t-test. Compared with IMRT, the VMAT plans achieved better PTV dose conformity, OAR dose-sparing, and smaller cold spots in the treatment of prostate cancer.

This research has been published in the Radiological Physics and Technology (RPT), 2019.02, (https://doi.org/10.1007/s12194-019-00502-0).

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

  • Research Products

    (3 results)

All 2019 2018 Other

All Journal Article (1 results) (of which Open Access: 1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Comparison of volumetric-modulated arc therapy and intensity-modulated radiation therapy prostate cancer plans accounting for cold spots2019

    • Author(s)
      Tran Thi Thao Nguyen, Hidetaka Arimura, Ryosuke Asamura, Taka-aki Hirose, Saiji Ohga, Jun-ichi Fukunaga
    • Journal Title

      Radiological Physics and Technology

      Volume: 1

    • DOI

      https://doi.org/10.1007/s12194-019-00502-0

    • Open Access
  • [Presentation] Computationally analysis of cold spots in dose distributions of VMAT plans for prostate cancer2018

    • Author(s)
      Tran Thi Thao Nguyen
    • Organizer
      the 18th Asia-Oceania Congress of Medical Physics (AOCMP) & the 16th South East Asia Congress of Medical Physics (SEACOMP), Malaysia, Kuala Lumpur
  • [Remarks] 有村研究室

    • URL

      http://web.shs.kyushu-u.ac.jp/~arimura/pg46.html

URL: 

Published: 2019-12-27  

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