Network analysis for prognostic factors of heart failure using longitudinal data from huge cohort data

2018 Fiscal Year Annual Research Report

• Project/Area Number: 16K00039
• Research Institution: Tohoku University
• Principal Investigator: 宮田 敏 東北大学, 医学系研究科, 准教授 (60360343)
• Co-Investigator(Kenkyū-buntansha): 坂田 泰彦 東北大学, 医学系研究科, 准教授 (90379206)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: コホート研究 / ネットワーク解析 / 構造方程式モデル / 慢性心不全

Outline of Annual Research Achievements

本研究では，2006~2010年に東北大学を含む東北地区24基幹病院において登録された10,219名の慢性心不全及びその高リスク患者を対象としたコホート（CHART-2研究）のデータを用い、ネットワーク解析を用いた疾患イベントのリスク要因探索を行った。
CHART-2研究では、各種死因による死亡や心不全による入院などのイベント情報の他、各種検査項目などの各年次のデータの収拾も継続中であり、本研究中に登録時から3年次までのデータを確定し経時データを用いた解析も開始した。
本研究の成果として、1）脳性ナトリウム利尿ペプチド（BNP）とN末端プロB型ナトリウム利尿ペプチド（NT-proBNP）の変換公式の開発、2）左室駆出率の保たれた心不全患者の簡便な予後予測スコアの開発、3）心不全患者の予後に対するセルフケアと性差の関係の解明、4）慢性心不全患者における左室駆出率と性差の関係の解明、等を行った。
また、昨年度から開始した経時データを関数データとして解析し，関数主成分分析を用いたデータの層別化と心不全患者の予後リスク層別化の研究については、理論的なモデル開発をほぼ終了し，現在シミュレーションのためのプログラム開発と、CHART-2研究登録患者を対象とした臨床応用について検討中である。
本研究の成果は，査読付き研究論文（本研究関連6件、その他10件）、国際学会（本研究関連14件、その他6件）、国内学会多数により報告した。また、CHART-2研究の研究主体である東北心不全協議会の第30，31回総会を開催し，研究の進捗を報告した。

Research Products

• [Journal Article] Cardiac Lymphatic Dysfunction Causes Drug-Eluting Stent?Induced Coronary Hyperconstricting Responses in Pigs In Vivo (2019)
  • Author(s): Amamizu Hirokazu、Matsumoto Yasuharu、Morosawa Susumu、Ohyama Kazuma、Uzuka Hironori、Hirano Michinori、Nishimiya Kensuke、Gokon Yusuke、Watanabe-Asaka Tomomi、Hayashi Moyuru、Miyata Satoshi、Kamei Takashi、Kawai Yoshiko、Shimokawa Hiroaki
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 39 Pages: 741～753
  • DOI: 10.1161/ATVBAHA.119.312396
  • Peer Reviewed / Open Access
• [Journal Article] Conversion formula from B-type natriuretic peptide to N-terminal proBNP values in patients with cardiovascular diseases (2019)
  • Author(s): Kasahara Shintaro、Sakata Yasuhiko、Nochioka Kotaro、Miura Masanobu、Abe Ruri、Sato Masayuki、Aoyanagi Hajime、Fujihashi Takahide、Yamanaka Shinsuke、Shiroto Takashi、Sugimura Koichiro、Takahashi Jun、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: International Journal of Cardiology Volume: 280 Pages: 184～189
  • DOI: 10.1016/j.ijcard.2018.12.069
  • Peer Reviewed / Open Access
• [Journal Article] Gender differences in prognostic relevance of self-care behaviors on mortality and hospitalization in patients with heart failure ? A report from the CHART-2 Study (2019)
  • Author(s): Abe Ruri、Sakata Yasuhiko、Nochioka Kotaro、Miura Masanobu、Oikawa Takuya、Kasahara Shintaro、Sato Masayuki、Aoyanagi Hajime、Shiroto Takashi、Sugimura Koichiro、Takahashi Jun、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: Journal of Cardiology Volume: 73 Pages: 370～378
  • DOI: 10.1016/j.jjcc.2018.11.006
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of residual stenosis after percutaneous coronary intervention in patients with ischemic heart failure ? A report from the CHART-2 study (2019)
  • Author(s): Hao Kiyotaka、Takahashi Jun、Sakata Yasuhiko、Miyata Satoshi、Shiroto Takashi、Nochioka Kotaro、Miura Masanobu、Oikawa Takuya、Abe Ruri、Sato Masayuki、Kasahara Shintaro、Aoyanagi Hajime、Shimokawa Hiroaki
  • Journal Title: International Journal of Cardiology Volume: 278 Pages: 22～27
  • DOI: 10.1016/j.ijcard.2018.10.062
  • Peer Reviewed / Open Access
• [Journal Article] The 3A3B score: The simple risk score for heart failure with preserved ejection fraction - A report from the CHART-2 Study (2019)
  • Author(s): Kasahara Shintaro、Sakata Yasuhiko、Nochioka Kotaro、Tay Wan Ting、Claggett Brian Lee、Abe Ruri、Oikawa Takuya、Sato Masayuki、Aoyanagi Hajime、Miura Masanobu、Shiroto Takashi、Takahashi Jun、Sugimura Koichiro、Teng Tiew-Hwa Katherine、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: International Journal of Cardiology Volume: 284 Pages: 42～49
  • DOI: 10.1016/j.ijcard.2018.10.076
  • Peer Reviewed / Open Access
• [Journal Article] Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia?-?Crucial roles of endothelial nitric oxide synthase (2018)
  • Author(s): Eguchi Kumiko、Shindo Tomohiko、Ito Kenta、Ogata Tsuyoshi、Kurosawa Ryo、Kagaya Yuta、Monma Yuto、Ichijo Sadamitsu、Kasukabe Sachie、Miyata Satoshi、Yoshikawa Takeo、Yanai Kazuhiko、Taki Hirofumi、Kanai Hiroshi、Osumi Noriko、Shimokawa Hiroaki
  • Journal Title: Brain Stimulation Volume: 11 Pages: 959～973
  • DOI: 10.1016/j.brs.2018.05.012
  • Peer Reviewed / Open Access
• [Journal Article] Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction (2018)
  • Author(s): Kagaya Yuta、Ito Kenta、Takahashi Jun、Matsumoto Yasuharu、Shiroto Takashi、Tsuburaya Ryuji、Kikuchi Yoku、Hao Kiyotaka、Nishimiya Kensuke、Shindo Tomohiko、Ogata Tsuyoshi、Kurosawa Ryo、Eguchi Kumiko、Monma Yuto、Ichijo Sadamitsu、Hatanaka Kazuaki、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: Coronary Artery Disease Volume: 29 Pages: 294～300
  • DOI: 10.1097/MCA.0000000000000577
  • Peer Reviewed / Open Access
• [Journal Article] Comparable prognostic impact of BNP levels among HFpEF, Borderline HFpEF and HFrEF: a report from the CHART-2 Study (2018)
  • Author(s): Kasahara Shintaro、On behalf of the CHART-2 Investigators、Sakata Yasuhiko、Nochioka Kotaro、Yamauchi Takeshi、Onose Takeo、Tsuji Kanako、Abe Ruri、Oikawa Takuya、Sato Masayuki、Aoyanagi Hajime、Miura Masanobu、Shiroto Takashi、Takahashi Jun、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: Heart and Vessels Volume: 33 Pages: 997～1007
  • DOI: 10.1007/s00380-018-1150-4
  • Peer Reviewed / Open Access
• [Journal Article] Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension (2018)
  • Author(s): Kikuchi Nobuhiro、Satoh Kimio、Kurosawa Ryo、Yaoita Nobuhiro、Elias-Al-Mamun Md.、Siddique Mohammad Abdul Hai、Omura Junichi、Satoh Taijyu、Nogi Masamichi、Sunamura Shinichiro、Miyata Satoshi、Saito Yoshiro、Hoshikawa Yasushi、Okada Yoshinori、Shimokawa Hiroaki
  • Journal Title: Circulation Volume: 138 Pages: 600～623
  • DOI: 10.1161/CIRCULATIONAHA.117.033113
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Significance of PR Interval Prolongation in Adult Patients With Total Correction of Tetralogy of Fallot (2018)
  • Author(s): Kimura Yoshitaka、Fukuda Koji、Nakano Makoto、Hasebe Yuhi、Fukasawa Kyoshiro、Chiba Takahiko、Miki Keita、Tatebe Shunsuke、Miyata Satoshi、Ota Hideki、Kimura Masato、Adachi Osamu、Saiki Yoshikatsu、Shimokawa Hiroaki
  • Journal Title: Circulation: Arrhythmia and Electrophysiology Volume: 11 Pages: 1-11
  • DOI: 10.1161/CIRCEP.118.006234
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Hepatitis C Virus Antibody-Positivity on Cardiac Function and Long-Term Prognosis in Patients With Adult Congenital Heart Disease (2018)
  • Author(s): Konno Ryo、Tatebe Shunsuke、Sugimura Koichiro、Satoh Kimio、Aoki Tatsuo、Miura Masanobu、Yamamoto Saori、Sato Haruka、Kozu Katsuya、Terui Yosuke、Miyata Satoshi、Adachi Osamu、Kimura Masato、Saiki Yoshikatsu、Shimokawa Hiroaki
  • Journal Title: The American Journal of Cardiology Volume: 122 Pages: 1965～1971
  • DOI: 10.1016/j.amjcard.2018.08.045
  • Peer Reviewed / Open Access
• [Journal Article] Sex differences in hemodynamic responses and long-term survival to optimal medical therapy in patients with pulmonary arterial hypertension (2018)
  • Author(s): Kozu Katsuya、Sugimura Koichiro、Aoki Tatsuo、Tatebe Shunsuke、Yamamoto Saori、Yaoita Nobuhiro、Shimizu Toru、Nochioka Kotaro、Sato Haruka、Konno Ryo、Satoh Kimio、Miyata Satoshi、Shimokawa Hiroaki
  • Journal Title: Heart and Vessels Volume: 33 Pages: 939～947
  • DOI: 10.1007/s00380-018-1140-6
  • Peer Reviewed / Open Access
• [Journal Article] Small GTP-Binding Protein GDP Dissociation Stimulator Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells (2018)
  • Author(s): Nogi Masamichi、Satoh Kimio、Sunamura Shinichiro、Kikuchi Nobuhiro、Satoh Taijyu、Kurosawa Ryo、Omura Junichi、Elias-Al-Mamun Md.、Abdul Hai Siddique Mohammad、Numano Kazuhiko、Kudo Shun、Miyata Satoshi、Akiyama Masatoshi、Kumagai Kiichiro、Kawamoto Shunsuke、Saiki Yoshikatsu、Shimokawa Hiroaki
  • Journal Title: Circulation Volume: 138 Pages: 2413～2433
  • DOI: 10.1161/CIRCULATIONAHA.118.035648
  • Peer Reviewed / Open Access
• [Journal Article] Sex Differences in Patients With Chronic Heart Failure With Reference to Left Ventricular Ejection Fraction (2018)
  • Author(s): Sakata Yasuhiko、Miyata Satoshi、Nochioka Kotaro、Miura Masanobu、Shiroto Takashi、Shimokawa Hiroaki
  • Journal Title: Gender and the Genome Volume: 2 Pages: 27～42
  • DOI: 10.1177/2470289718787115
  • Peer Reviewed / Open Access
• [Journal Article] Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice (2018)
  • Author(s): Sunamura Shinichiro、Satoh Kimio、Kurosawa Ryo、Ohtsuki Tomohiro、Kikuchi Nobuhiro、Elias-Al-Mamun Md.、Shimizu Toru、Ikeda Shohei、Suzuki Kota、Satoh Taijyu、Omura Junichi、Nogi Masamichi、Numano Kazuhiko、Siddique Mohammad Abdul Hai、Miyata Satoshi、Miura Masahito、Shimokawa Hiroaki
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 115 Pages: E7129～E7138
  • DOI: 10.1073/pnas.1721298115
  • Peer Reviewed / Open Access
• [Journal Article] Structural brain abnormalities and cardiac dysfunction in patients with chronic heart failure (2018)
  • Author(s): Suzuki Hideaki、Matsumoto Yasuharu、Ota Hideki、Sugimura Koichiro、Takahashi Jun、Ito Kenta、Miyata Satoshi、Fukumoto Yoshihiro、Taki Yasuyuki、Shimokawa Hiroaki
  • Journal Title: European Journal of Heart Failure Volume: 20 Pages: 936～938
  • DOI: 10.1002/ejhf.1104
  • Peer Reviewed / Open Access
• [Presentation] Prognostic impact of diabetes mellitus in patients with chronic heart failure -With special references to ischemic heart disease and nephropathy- (2018)
  • Author(s): Miura M, Sakata Y, Sato M, Abe R, Kasahara S, Aoyanagi H, Fujihashi T, Yamanaka S, Shiroto T, Nochioka K, Sugimura K, Takahashi J, Miyata S, Shimokawa H
  • Organizer: Heart Failure Seoul 2018 (Seoul, Korea)
  • Int'l Joint Research
• [Presentation] SmgGDS prevents thoracic aortic aneurysm formation and rupture by phenotypic preservation of aortic smooth muscle cells (2018)
  • Author(s): Nogi M, Satoh K, Kudo S, Sunamura S, Kikuchi N, Satoh T, Kurosawa R, Omura J, Al-Mamun E, Siddique MA, Numano K, Miyata S, Akiyama M, Kumagai S, Saiki Y, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of soluble basigin in patients with chronic heart failure -the novel aspect of the multifunctional inflammatory protein (2018)
  • Author(s): Satoh K, Miyata S, Ohtsuki T, Nochioka K, Miura M, Shiroto T, Sunamura S, Nogi M, Kurosawa R, Kikuchi N, Satoh T, Sakata Y, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Clinical characteristics, prognosis and prognostic factors of elderly patients with chronic heart failure: A report from the CHART-2 Study (2018)
  • Author(s): Sato M, Sakata Y, Nochioka K, Miura M, Kasahara S, Aoyanagi H, Fujihashi T, Yamanaka S, Abe R, Oikawa T, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Benefit and risk of antithrombotic therapy in patients with atrial fibrillation -A report from the CHART-2 Study- (2018)
  • Author(s): Shiroto T, Sakata Y, Nochioka K, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Yamanaka S, Fujihashi T, Miura M, Takahashi J, Miyata S, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Elevated serum triglyceride level as a significant residual risk for acute myocardial infraction in patients with stable ischemic heart disease under statin treatment -A report from the CHART-2 Study- (2018)
  • Author(s): Suzuki K, Oikawa T, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Takahashi J, Miyata S, Sakata Y, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of serum levels of selenoprotein P in patients with pulmonary arterial hypertension (2018)
  • Author(s): Kikuchi N, Satoh K, Tanaka M, Kato S, Omura J, Satoh T, Kurosawa R, Nogi M, Sunamura S, Yaoita N, Miyata S, Misu H, Saito Y, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Simple risk model for heart failure with preserved ejection fraction -A report from the CHART-2 Study (2018)
  • Author(s): Kasahara S, Sakata Y, Nochioka K, Abe R, Sato M, Aoyanagi H, Fujihashi T, Yamanaka S, Miura M, Shiroto T, Takahashi J, Sugimura K, Miyata S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of impaired coronary vasodilator function and enhanced vasoconstriction responses in patients with angina and unobstructive coronary arteries (2018)
  • Author(s): Suda A, Takahashi J, Hao K, Kikuchi Y, Shindo T, Ikeda S, Sato K, Sugisawa J, Matsumoto Y, Miyata S, Sakata Y, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impact of temporal changes in left ventricular ejection fraction in patients with stage B heart failure (2018)
  • Author(s): Aoyanagi H, Sakata Y, Nochioka K, Miura M, Shiroto T, Abe R, Kasahara S, Sato M, Fujihashi T, Yamanaka S, Sugimura K, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions (Chicago, Illinois, USA)
  • Int'l Joint Research
• [Presentation] Development of useful conversion equation between B-type natriuretic peptide and N-terminal pro BNP levels. (2018)
  • Author(s): Kasahara S, Sakata Y, Nochioka K, Abe R, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Sugimura K, Miyata S, Shimokawa H.
  • Organizer: 22nd Annual Scientific Meeting of Heart Failure Society of America (HFSA) (Nashville, USA)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of soluble form of basigin in patients with chronic heart failure -from a prospective large clinical trial with 1,147 patients- (2018)
  • Author(s): Satoh K, Miyata S, Miura M, Ohtsuki T, Nochioka K, Sunamura S, Nogi M, Kurosawa R, Kikuchi N, Satoh T, Aoki T, Tatebe S, Sugimura K, Sakata Y, Shimokawa H.
  • Organizer: ESC Congress 2018 (Munich, Germany)
  • Int'l Joint Research
• [Presentation] Prognostic impacts of impaired coronary vasodilatation and enhanced coronary vasoconstricting responses in patients with angina and unobstructive coronary arteries. (2018)
  • Author(s): Suda A, Takahashi J, Hao K, Kikuchi Y, Shindo T, Sato K, Sugisawa J, Matsumoto Y, Miyata S, Sakata Y, Shimokawa H.
  • Organizer: ESC Congress 2018 (Munich, Germany)
  • Int'l Joint Research
• [Presentation] Clinical impacts of wide ORS morphologies on deterioration of left ventricular ejection fraction and fatal arrhythmias in patients with relatively preserved left ventricular ejection function. (2018)
  • Author(s): Kimura Y, Nakano M, Sakata Y, Nochioka K, Hasebe Y, Abe R, Chiba T, Fukasawa K, Oikawa T, Kasahara S, Miki K, Sato M, Shiroto T, Miyata S, Shimokawa H.
  • Organizer: ESC Congress 2018 (Munich, Germany)
  • Int'l Joint Research
• [Presentation] Impact of temporal changes in left ventricular ejection fraction in patients at risk for heart failure. (2018)
  • Author(s): Aoyanagi H, Sakata Y, Nochioka K, Shiroto T, Oikawa T, Abe R, Kasahara S, Sato M, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: ESC Congress 2018 (Munich, Germany)
  • Int'l Joint Research
• [Presentation] Increased risk of cancer death in patients with chronic heart failure with a special reference to inflammation and diabetes mellitus -A report from the CHART-2 Study (2018)
  • Author(s): Sakata Y, Oikawa T, Nochioka K, Miura M, Abe R, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Sugimura K, Takahashi J, Miyata S, Shimokawa H
  • Organizer: Heart Failure 2018 (Vienna, Austria)
  • Int'l Joint Research
• [Presentation] Sex differences in temporal changes in left ventricular ejection fraction among patients with heart failure -A report from the CHART-2 Study- (2018)
  • Author(s): Tsuji K, Sakata Y, Nochioka K, Miura M, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Shiroto T, Takahashi J, Miyata S, Shimokawa H
  • Organizer: Heart Failure 2018 (Vienna, Austria)
  • Int'l Joint Research
• [Presentation] Association between impaired glucose tolerance and prognosis according to presence of microalbuminuria in patients with chronic heart failure (2018)
  • Author(s): Nochioka K, Sakata Y, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H
  • Organizer: Heart Failure 2018 (Vienna, Austria)
  • Int'l Joint Research
• [Presentation] Derivation and validation of a conversion equation between B-type natriuretic peptide and N-terminal pro BNP levels (2018)
  • Author(s): Kasahara S, Sakata Y, Nochioka K, Abe R, Oikawa T, Sato M, Aoyanagi H, Miura M, Shiroto T, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: Heart Failure 2018 (Vienna, Austria)
  • Int'l Joint Research
• [Presentation] Antithrombotic therapy improves long-term prognosis in patients with atrial fibrillation and heart failure -A report from the CHART-2 Study (2018)
  • Author(s): Shiroto T, Sakata Y, Nochioka K, Abe R, Oikawa T, Kasahara S, Sato M, Aoyanagi H, Miura M, Takahashi J, Miyata S, Shimokawa H.
  • Organizer: Heart Failure 2018 (Vienna, Austria)
  • Int'l Joint Research