2018 Fiscal Year Final Research Report
Identificaiton of nutritional factors which suppress SASP
| Project/Area Number |
16K00878
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Sugiyama Jogakuen University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Keywords | 細胞老化 / 老化 / SASP / 炎症 |
|---|
| Outline of Final Research Achievements |
Cellular senescence, especially senescence-associated secretory phenotype (SASP), have been implicated in the development of several age-related diseases and aging. Thus, the regulation of SASP is a potent target for preventive and clinical treatment of age-related diseases. In this study, I have identified the components derived from food and natural product which suppress SASP. Carotenoid in water melon and alkaroid in Evodia rutaecarpa suppressed the expression of SASP components without inhibiting cellular senescence induction.
|
| Free Research Field |
分子細胞生物学
|
| Academic Significance and Societal Importance of the Research Achievements |
老化および老年性疾患の発症に関与する細胞老化付随分泌現象（SASP）を抑制する天然物・食品由来の成分の同定を行った。これらの研究成果から薬ではなく「食の面から健康を支える」ことのできる予防効果が期待される食品・天然物を示すことができる可能性が期待される。
|
