Degeneration of elastic fiber architecture of blood vessels in high salt induced hypertension and effect of decrease of salt.

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K00910
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Okayama University
• Principal Investigator: Ohtsuka Aiji 岡山大学, 医歯薬学総合研究科, 教授 (50168986)
• Co-Investigator(Kenkyū-buntansha): 品岡 玲 岡山大学, 医歯薬学総合研究科, 助教 (90724500)
• Research Collaborator: NARASAKI Masahiro
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 高血圧 / 冠状動脈 / 弾性線維 / 走査電子顕微鏡 / 血管鋳型樹脂注入後消化法 / ラット

Outline of Final Research Achievements

The structure of the blood vessel consists of a three-layer structure of the intima, media and adventitia from inside to outside. In particular, the tunica media has many smooth muscles and elastic fibers, and it plays an important role in regulating diameter of blood vessel and controlling blood pressure. In this study, we observed how the elastic fiber network changes in high blood pressure using the latest scanning electron microscopy technology. In hypertension induced by high salt diet, it has been shown to increase in the elastic fibers density of the coronary arteries, including arterioles, in the heart, suggesting an association with coronary circulation and its pathogenesis in coronary disorders. Effect of decrease of salt in diet is still under research.

Free Research Field

解剖学

Academic Significance and Societal Importance of the Research Achievements

これまで、血管壁の弾性線維構造については、太い動脈についてのみ知られていたが、細い血管ではその立体構造は観察されていない。この研究は、細い血管まで見る技術を駆使して観察したところ、高血圧が弾性線維構造に影響することが判明しました。心疾患は日本人の死因の第2位を占めていますが、この研究は、将来の冠状動脈疾患（狭心症や心筋梗塞）の病態の解明と治療に貢献すると考えられます。