Effects of longitudinally nutritional intervention on sarcopenia in patients with nonalcoholic fatty liver disease

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K01795
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kagawa Prefectural College of Health Sciences
• Principal Investigator: Himoto Takashi 香川県立保健医療大学, 保健医療学部, 教授 (20325343)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 非アルコール性脂肪性肝疾患 / サルコペニア / サルコペニア肥満 / 栄養介入 / 四肢骨格筋量 / 体脂肪量

Outline of Final Research Achievements

The aim of this study was to reveal the frequencies of pre-sarcopenia, sarcopenia and sarcopenic obesity in patients with nonalcoholic fatty liver disease (NAFLD), and to determine the biochemical and nutritional factors associated with skeletal muscle index (SMI) in those patients. Three of the 24 (13%) male and four of the 22 (18%) female NAFLD patients fulfilled the criteria for pre-sarcopenia, and one (5%) female NAFLD patient was in the criteria for sarcopenia. None of the patients were in the criteria for sarcopenic obesity. The factors associated with SMI in the males were body mass index (BMI), IGF-1, total energy intake and lipid intake, but only BMI and bone mineral density in females. The diet intervention decreased the skeletal muscle mass in the 6 males by decreasing the total energy intake via lower protein and lipid intakes. In the 13 females, a decrease in total energy intake via lower carbohydrate and lipid intake did not change the skeletal muscle mass.

Free Research Field

総合診療医学

Academic Significance and Societal Importance of the Research Achievements

非アルコール性脂肪性肝疾患 (NAFLD) 患者における四肢骨格筋量の低下は，非肥満者で体脂肪率の高い（いわゆる“隠れ肥満”）患者に多くみられ，NAFLD患者にはサルコペニア肥満がみられないことを明らかにした。また，四肢骨格筋量を規定する因子は男女で異なり，性別を考慮して治療介入しなければならないことも明らかとなった。さらに，非肥満者のNAFLD患者に栄養介入する際には，脂肪肝が改善しても四肢骨格筋量が低下することがあり，四肢骨格筋量にも注意しながら栄養介入しなければならないことが示唆された。