changing role of vagal nerve by aging and obesity

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K01815
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kanazawa University
• Principal Investigator: Kimura Kumi 金沢大学, 医学系, 助教 (60409472)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 自律神経 / インスリン抵抗性

Outline of Final Research Achievements

In this study, we used DMV-hM3Dq / DMV-hM4Di mice and examined effects of aging and obesity on changing role of vagal nerve. In DMV-hM3Dq mice, CNO administration activated vagus nerve activity and induced insulin secretion, immediately. In DMV-hM4Di mice, CNO administration suppressed vagus nerve activity and inhibited insulin secretion, transiently. However, these mice (both DMV-hM3Dq and DMV-hM4Di) exhibited elevation of blood glucose levels by treatment with ligand. These data suggested a need for analysis of other hormones except for insulin.

Free Research Field

生活習慣病

Academic Significance and Societal Importance of the Research Achievements

自律神経を介した肝臓代謝調節の加齢・肥満による変化を解明することは、加齢・肥満における生活習慣病の病態理解を深め、多様な疾患が合併する生活習慣病の新たな予防法の開発を可能にすると考えている。