Elucidation of concept of ectopic fat consortium of cardiac fat, ectopic fat and sarcopenia and life-style diseases

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K01823
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Fukushima Medical University
• Principal Investigator: Shimabukuro Michio 福島県立医科大学, 医学部, 教授 (60271144)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 異所性脂肪 / 糖尿病 / 心臓血管病

Outline of Final Research Achievements

The purpose of this study is: First, to investigate the clinical significance of cardiac fat, ectopic fat, and sarcopenia, the pathological significance of lifestyle-related diseases, and the onset and progression of cardiovascular diseases; Second, to verify the physiologically active substances derived from the ectopic fat and to elucidate the molecular mechanisms involved in the pathophysiology of of ectopic fat in lifestyle-related diseases and cardiovascular diseases; Third, to buidl a new concept considering cardiac fat, ectopic fat, and sarcopenia.

Free Research Field

代謝学

Academic Significance and Societal Importance of the Research Achievements

本研究では、第一に心臓脂肪・異所性脂肪・サルコペニアの存在様式が生活習慣病・心臓血管病の発症・進展におよぼす病的意義を解明する、第二に心臓脂肪・異所性脂肪由来の生理活性物質を網羅的に検証し、生活習慣病・心臓血管病の病態に関わるメカニズムを解明する、第三に心臓脂肪・異所性脂肪・サルコペニアを考慮した新しい診療コンセプトを構築する、ことを目的とした。“心臓脂肪・異所性脂肪・サルコペニアの生活習慣病、心臓血管病の発症における病的意義の解明”という課題の解決に関わる成果をあげ、学術的、社会的意義を有する。