Novel roles of ghrelin and neuromedin U in the motivation for voluntary exercise at the reset time of the circadian rhythm

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K01847
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kurume University
• Principal Investigator: MIFUNE Hiroharu 久留米大学, 医学部, 准教授 (70174117)
• Co-Investigator(Kenkyū-buntansha): 満園 良一 久留米大学, 人間健康学部, 教授 (20200058) ; 田尻 祐司 久留米大学, 医学部, 教授 (80469361)
• Research Collaborator: KOJIMA Masayasu
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 概日リズム / 自発運動 / グレリン / ニューロメジンU / 遺伝子欠損マウス / 時限制限給餌 / 恒常暗

Outline of Final Research Achievements

Circadian rhythmicity as a base of biological clock is entrained by extrinsic stimuli such as light or food consumption (resetting machinery). The aim of this study is to clarify possible roles of ghrelin (appetite-stimulating hormone) and neuromedin U (appetite-suppressing hormone) on regulating voluntary exercise as a part of resetting machinery of circadian rhythm. Furthermore, we explored a crucial role of central or peripheral clock on regulating voluntary exercise as a part of resetting machinery of circadian rhythm. Form the results obtained in this study, the relevance of both appetite-regulating hormones to resetting machinery of circadian rhythmicity.

Free Research Field

内分泌代謝学，健康スポーツ科学，実験動物学

Academic Significance and Societal Importance of the Research Achievements

グレリン・ニュロメジンUなど生体リズムに関与する因子の機能解析を通じて自発運動制御機構と生体内リズム調節機構を包括的に理解し、それらの相互関係を解明した本研究成果は、今後、様々な生活習慣病の有効な予防法としての食事・運動療法に新たな側面からのアプローチ方法をもたらし、時間運動学的観点から新しい指導概念（食事のタイミングや規則性、運動の時間帯への配慮等）の導入が期待される。