2018 Fiscal Year Annual Research Report
Bio-friendly nanosheets loaded with laser-generated nano-containers that release metal ions to accelerate wound healing
| Project/Area Number |
16K04904
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| Research Institution | Tokai University |
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Principal Investigator |
クリニッチ セルゲイ 東海大学, 総合科学技術研究所, 教授 (00623092)
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| Co-Investigator(Kenkyū-buntansha) |
岡村 陽介 東海大学, 工学部, 准教授 (40365408)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | Laser ablation / Nanoparticles / Nanocontainers / Polymer nanosheets / Ion release / Wound dressing / Antibacterial behavior |
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| Outline of Annual Research Achievements |
During year tree, we worked on:
(1) Preparing various Fe-containing nanoparticles (metallic Mg, FeClx, FeOx) via laser ablation in liquid phase (mainly in chloroform). (2) Preparing poly-L-lactic acid (PLLA) nanosheets embedded with such nanoparticles containing Fe ions and characterizing the prepared nanosheets. (3) Evaluating how Fe ions are released from nanosheets into physiological solution over time. The dynamics of Fe ion release from prepared nanosheets was evaluated upon placing the nanosheets into buffer solution with pH 7.4 and at temperature of 37 C. The tested nanosheets demonstrated very fast Fe ion release dynamics: maximum concentrations were achieved within ~5 upon immersion. This was much faster than ion release observed from Zn-ion-incorporated PLLA nanosheets studied before. (4) Preparing ZnO nanoparticles via laser ablation in water and air and comparing properties of the two products (including their antibacterial performance after incorporation into biomedical materials made of PLLA. (5) We also prepared ZnO nanoparticles using nanosecond and millisecond pulsed lasers and compared their photocatalytic properties against methylene blue. And finally, some of laser-generated ZnO nanomaterials were used as sensing element deposited onto QCM for ethanol detection.
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