Construction of hollow spherical particles composed of macrocycles with functional groups

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K05801
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Polymer chemistry
• Research Institution: Tokushima Bunri University
• Principal Investigator: Tominaga Masahide 徳島文理大学, 薬学部, 准教授 (60361507)
• Research Collaborator: KATAGIRI Kosuke 甲南大学, 理工学部, 准教授 (90412395) ; MASU Hyuma 千葉大学, 大学院工学研究科, 准教授 (80412394)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 環状化合物 / 自己集合 / 球状粒子 / 分子集合体 / 動的挙動 / 相転移 / 発光特性 / 溶媒効果

Outline of Final Research Achievements

A series of adamantane-bearing macrocycles possessing diverse sizes, shapes, conformations, and functional groups were designed and synthesized. These compounds were self-assembled into hollow spherical particles, whose formation are attributed to solvophobic interactions derived from the aliphatic character of adamantane parts in macrocycles. The sizes, stabilities, and internal structures of hollow spherical particles were mostly dependent to the substituents on the macrocyclic frameworks and used solvents. The external stimuli including polarity of solvents, temperature, and guest addition caused the change of their sizes and morphologies, and phase transition from amorphous to crystalline materials. Further, the shapes and morphologies of self-assembled architectures and the introduced functional groups on macrocycles affect directly each property such as fluorescence and wettability.

Free Research Field

有機化学

Academic Significance and Societal Importance of the Research Achievements

独自の分子設計指針による多彩な形状・サイズ・機能性官能基を有する環状分子群の合成と、これを基盤とした中空球状微粒子ライブラリーの構築および機能創出に取り組んでいる研究は限られている。このようなナノからミクロンサイズの中空球状微粒子を基盤とする技術は、製薬や食品などのバイオサイエンスの分野から触媒、塗料、電池などのマテリアルサイエンスの分野まで幅広く活用できる可能性がある。得られた成果は自己組織化化学や超分子化学などのナノサイエンスの分野、特にベシクルやナノ微粒子の研究領域に有用な知見と有意な波及効果をもたらすと思われる。