Unravelling Mechanisms Underlying Termination of Neuronal Migration

2019 Fiscal Year Annual Research Report

• Project/Area Number: 16K07010
• Research Institution: National Institute of Genetics
• Principal Investigator: ZHU YAN 国立遺伝学研究所, 遺伝形質研究系, 助教 (50464235)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: tangential migration / migration termination / RNA-seq / Contactin-2 / Secretase / Chain migration

Outline of Annual Research Achievements

To study mechanisms underlying termination of tangential neuronal migration, we performed RNA-seq transcriptome profiling and functional analyses of adhesion molecule CNTN2. We have identified several candidate genes and demonstrated the involvement of a pair of transcription factors. We have also unveiled a role of CNTN2 in chain migration and an importance of its down-regulation by secretases for proper termination.

Research Products

• [Presentation] Contactin-2 (Tag-1) and its processing: in neuronal migration and the making of pontine nuclei (2020)
  • Author(s): Zhu Y, Masuda A, Hirata T
  • Organizer: International Symposium on Neural Develpoment, Regeneration & Diseases
  • Int'l Joint Research
• [Presentation] Mechanisms underlying termination of tangential neuronal migration investigated by a RNA-sesq based approach (2019)
  • Author(s): Masuda A, Nakaoka H, Toyoda A, Hirata T, Zhu Y
  • Organizer: Spring Meeting of the Japanese Society of Genetics