The elucidation of molecular pathological condition in prion disease: analysis of interferon system to develop novel therapeutic method

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K07042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Nagasaki University
• Principal Investigator: ISHIBASHI Daisuke 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (10432973)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: プリオン / 自然免疫 / インターフェロン

Outline of Final Research Achievements

In this study, we investigated a relationship of between type I interferon in innate immune responses and prion infection to host. As a result, we defined that innate immune system mediating type I interferon receptor might negatively regulate prion invasion to host. In the future, we believe that our project will be promoted development of prevention and drug for prion disease.

Free Research Field

ウイルス学、免疫学、分子生物学

Academic Significance and Societal Importance of the Research Achievements

これまで注目されてこなかった自然免疫機構を視点としたプリオン感染病態メカニズムの解明について研究を遂行することにより、治療法がないプリオン病の創薬開発が進むことが期待される。