2017 Fiscal Year Research-status Report
Novel murine model of congenital diabetes
| Project/Area Number |
16K07094
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| Research Institution | Kitasato University |
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Principal Investigator |
佐々木 宣哉 北里大学, 獣医学部, 教授 (20302614)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | Insulin / Diabetes / Pancreatic islet / Mutant |
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| Outline of Annual Research Achievements |
This year, we characterized the ihs mice more. The ihs mice exhibited several distinctive diabetes-related characteristics: (1) diabetes was observed in male but not female mice; (2) there were no differences in insulin content between the ihs and control mice; (3) impaired insulin secretion was elicited by glucose, potassium chloride and sulfonylureas; (4) they exhibited a normal glycemic response to exogenous insulin; and (5) the mice were not obese. The ihs mouse provides a novel murine model of congenital diabetes that exhibits insulin secretion failure. This model allows not only an analysis of the progression of diabetes, but also the identification of unknown genes involved in insulin secretion.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
糖尿病原因遺伝子座の同定に成功し候補遺伝子を3個までに絞り込んだ。
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| Strategy for Future Research Activity |
KOマウスを作出することによって原因遺伝子の同定および発症メカニズムの解析を行う。
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| Causes of Carryover |
少額の誤差であり、次年度は消耗品に計上する。
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