Identification and fuctional analysis of a novel molecular signal network related to NF1 tumorigenesis via the activation of translation mediated by TCTP

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K07118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Niigata University (2019); Kumamoto University (2016-2018)
• Principal Investigator: Kobayashi Daiki 新潟大学, 医歯学系, 助教 (20448517)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: NF1 / TCTP / 悪性腫瘍 / EF1A2 / 翻訳伸長因子

Outline of Final Research Achievements

In order to elucidate the pathogenesis of neurofibromatosis type 1 (NF1), we investigated the role of TCTP-mediated translational control mechanism in NF1 tumor cells. TCTP significantly binds to the translation elongation factor complex, and in particular, TCTP forms a complex with the translation elongation factors including EF1A2, which promotes protein translation in NF1 tumor cells. Therefore, This study demonatrates that TCTP promotes the pathogenesis of NF1 tumor by activating the protein translation elongation by interacting with EF1A2.

Free Research Field

腫瘍生物学

Academic Significance and Societal Importance of the Research Achievements

神経線維腫症１型（NF1）は悪性腫瘍を含む多彩な病態を示す遺伝性疾患である。NF1の詳細な分子機序や病態マーカーおよび治療標的は報告されておらず、治療法は対処療法のみである。本研究により、TCTPを介した翻訳制御機構が明らかとなり、NF1腫瘍の病態を進行させていることが考えられ、その機能阻害がNF1腫瘍の治療標的として有効であることが示唆された。