Identification of a dormant cancer stem cell-related gene

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K07132
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: Tamai Keiichi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん幹細胞研究部, 部長 (40509262)
• Co-Investigator(Kenkyū-buntansha): 三浦 康 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (40282074)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 癌幹細胞

Outline of Final Research Achievements

We tried to identify the molecular mechanisms of cancer stem cells in cholangiocarcinoma. We identified several molecules which required for the maintenance of cancer stem cells. Our data demonstrated the possible therapeutic approach which transform the cancer stem cells into the non-cancer stem cells.

Free Research Field

腫瘍生物学

Academic Significance and Societal Importance of the Research Achievements

本研究は胆管癌の新たな治療標的を見いだした点で社会的意義が高い。