Roles for the pace control of neurogenesis in brain histogenesis

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K07375
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Kumamoto University
• Principal Investigator: Shimamura Kenji 熊本大学, 発生医学研究所, 教授 (70301140)
• Co-Investigator(Kenkyū-buntansha): 畠山 淳 熊本大学, 発生医学研究所, 助教 (90404350)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 神経発生 / 組織構築 / 神経幹細胞 / 神経分化 / ニューロン / 脳発生 / 大脳皮質

Outline of Final Research Achievements

We found that the transient retention of the apical endfoot of differentiating cells regulates the pace of neuron production through Notch signaling. We extend this notion to explore its role in brain histogenesis. We found that the retention period is correlated with the pace of neuron production in developing cerebral cortex and that the proper time length of retention is crucial for formation of well-proportioned six-layered structure of cerebral cortex. These results were published in Cerebral Cortex.

Free Research Field

発生生物学

Academic Significance and Societal Importance of the Research Achievements

ニューロン産生量の時間的調節機構について、およびそれが大脳皮質織構築にはたす役割について初めて明らかにした。皮質構築異常は、多くの先天性脳疾患、精神疾患等で報告されており、これらの疾患の病因・病態解明、治療法の開発に寄与する可能性がある。