Analysis and applications of the protective role of ether phospholipids on arteriosclerosis

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K07728
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Iwate University
• Principal Investigator: Nishimukai Megumi 岩手大学, 農学部, 准教授 (40374730)
• Research Collaborator: YAMAZAKI YUYA 株式会社ADEKA
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: エーテル型リン脂質 / 動脈硬化 / 閉経

Outline of Final Research Achievements

In this study, we investigated the involvement of ether-type phospholipids including plasmalogen on arteriosclerosis using cultured cells and animals, and it has been shown that plasmalogen is involved in the cholesterol efflux in peripheral tissues. Also, our findings indicate that plasmalogen is decreased in the blood with aging and ovariectomy, suggesting that plasmalogen may be involved in postmenopausal arteriosclerosis. These findings indicate the novel function of ether phospholipids and could contribute to the human health.

Free Research Field

脂質生理学

Academic Significance and Societal Importance of the Research Achievements

動脈硬化症、さらに閉経後の動脈硬化症にもエーテル型リン脂質の関与を示唆する結果を得た。この結果は、エーテル型リン脂質の新たな生理機能を提案するとともに、ヒトの健康に大きく寄与しうるものである。