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2018 Fiscal Year Final Research Report

Molecular basis for onset of the novel 3rd toxicity of cyanotoxin microcystin-LR

Research Project

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Project/Area Number 16K07875
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Aquatic life science
Research InstitutionKagoshima University

Principal Investigator

Komatsu Masaharu  鹿児島大学, 農水産獣医学域水産学系, 教授 (30325815)

Research Collaborator Takumi Shota  
Project Period (FY) 2016-04-01 – 2019-03-31
Keywordsマイクロシスチン / OATP1B3 / アノイキス抵抗性 / 上皮・間葉転換 / 間葉・上皮転換
Outline of Final Research Achievements

HEK293-OATP1B3FL (FL cells) and HEK293-OATP1B3AD (AD cells), which were transfomed cells after the parental HK293-OATP1B3 cells were exposed to MC-LR, were resistant to hypoxia than their parental cells.
Attenuation activity to the MC-LR cytotoxicity was detected in herbal medicines Iwajisha and Kin-oshi. In addition, we found that their components, acteoside, quercetin, and kaempferol were the active substances.

Free Research Field

毒性学

Academic Significance and Societal Importance of the Research Achievements

アオコに由来する肝臓毒マイクロシスチンLRは,高濃度で肝機能不全を誘発し,低濃度慢性曝露により肝臓がんの発がん物質として作用する。本研究により,マイクロシスチンLRに肝がんの浸潤・転移を誘発する可能性があることを実験室レベルで示した。また,マイクロシスチンLRの細胞毒性を抑制する化合物を生薬中に見出した。発見した物質は野菜や果物にも含まれる成分であり,生薬や食事によりマイクロシスチンLR中毒を予防でき,また,発がんおよびがんの転移を抑える可能性が示唆された。

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Published: 2020-03-30   Modified: 2020-07-01  

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