Studies of roles of inflammatory bioactive molecules on feeding regulation in chicks

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K07991
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Animal production science
• Research Institution: Ehime University
• Principal Investigator: Tachibana Tetsuya 愛媛大学, 農学研究科, 准教授 (80346832)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: ニワトリヒナ / 摂食行動 / 炎症性物質

Outline of Final Research Achievements

The present study revealed that intracerebroventricular or intraperitoneal injection of interleukin-1β, tumor-necrosis factor-like cytokine-1A, prostaglandin E2 (PGE2), PGF2α and PGD2 decreased food intake in chicks. In addition, the injection of IL6, IL8, interferon-α (IFNα) and IFNγ, which suppress feeding behavior in rodents, had no effect on food intake in chicks. Intraperitoneal injection of lipopolysaccharide, which is a component of Gram-negative bacteria, and poly I:C, which is a synthetic double-stranded RNA suppressed feeding behavior with induction of gene expression of cytokines and PGs noted above. These results suggested that these cytokines and PGs would be related to anorexia inducec by infection of bacteria and virus in chicks.

Free Research Field

家畜栄養学　家畜行動学　家畜生理学

Academic Significance and Societal Importance of the Research Achievements

病原性微生物の感染により、ニワトリは食欲不振に陥り、さらにはその生産性が低下する。この食欲不振には免疫に関わる炎症性物質が関わると考え、本研究ではニワトリヒナの摂食を抑制する炎症性物質の探索を進め、いくつかの炎症性物質がニワトリの摂食を抑制することを明らかにした。この成果は、ニワトリの摂食調節機構の解明を進めるものであるとともに、ニワトリの免疫系の解明に有用な情報を与えることができるものである。本研究の成果を基礎として今後の研究の発展させることで、感染時の食欲不振に伴う生産性の低下の防止に寄与できると考えられる。