Development of Novel Solid-phase Reaction System Based on fluorous chemistry

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K08184
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Meijo University
• Principal Investigator: HAMAMOTO HIROMI 名城大学, 農学部, 准教授 (40365896)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 固相試薬 / 酸化反応 / 機能性高分子 / フッ素系アルコール

Outline of Final Research Achievements

The use of a novel reaction medium provided by functionalized polymers could often bring a new strategy in the design of reagent or catalyst recycling systems. This work focused on the fluorous chemistry in the development of solid phase reaction medium using synthetic or natural polymers. The reaction medium provided by a fluorous PVP-type polymer was suitable for the activation of hypervalent iodine mediated oxidative amidation of p-cresol. The reaction medium provided by fluorous PAAm-type polymers was suitable for the activation of NHPI (or Laccase-TEMPO) catalyzed aerobic oxidations.

Free Research Field

有機化学

Academic Significance and Societal Importance of the Research Achievements

一般的な高分子等を利用する固相反応系は、試薬の回収・再利用が可能になり、試薬由来有害物の混入リスクの低減を可能にするため、医薬品の製造上重要であるが、均一溶液系反応と比べて反応性が低下するのが課題であった。均一溶液系と同等以上の活性発現が可能な固相反応系を設計するための新たなアプローチを示した本成果は、触媒化学・機能材料化学分野研究と融合させることにより安全な医薬品製造プロセスや環境低負荷型製造プロセスの開発に繋がる。