2018 Fiscal Year Final Research Report
Functional analysis of stem cell derived-Abeta phagocytic cells for the development of cell therapeutic strategies in Alzheimer's disease
| Project/Area Number |
16K08286
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Research Collaborator |
Ashihara Eishi
Kitamura Yoshihisa
Shimohama Shun
Chisaki Yugo
Toda Yuki
Nakata Susumu
Yano Yoshitaka
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | Alzheimer's disease / microglia / phagocytosis / amyloid-beta / clearance / stem cells / bone marrow cells / transplantation |
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| Outline of Final Research Achievements |
Alzheimer’s disease (AD) is a progressive neurodegenerative disease, and the development of more effective therapy is urgently required. Amyloid-β (Aβ) is thought to be a causative peptide for the development of AD. Microglia are brain immune cells and contribute to the clearance of Aβ in brains by their phagocytic function. In this study, mouse bone marrow derived-microglia like (BMDML) Aβ phagocytic cells were prepared and injected into brains of a mouse models of AD. As the results, BMDML cells recognized and decreased accumulations of Aβ in brains by their phagocytic function. Furthermore, the transplantation of BMDML cells attenuated the cognitive impairment in a model mouse of AD. Further studies using induced pluripotent stem (iPS) cells and/or embryonic stem (ES) cells are expected to contribute to the clinical application of cell therapeutic strategy against AD.
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| Free Research Field |
神経科学
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| Academic Significance and Societal Importance of the Research Achievements |
現在アルツハイマー病（AD）に対する治療は期間も効能も限定的な対症療法のみである。そこで発症機序に根差したより根本的な治療法の開発が必要である。本研究では、骨髄細胞から脳の免疫担当細胞であるミクログリア様の細胞を作製して脳内に移植すると、AD発症における原因物質であるアミロイドβの脳内蓄積量が減少し、さらには認知記憶障害をも改善し得ることをADモデルマウスを用いて明らかとした。この成果は、社会問題にまで発展するADに対する全く新しい細胞治療法の開発を提案するものであり、もって人類の福祉に大きく貢献できる可能性を有する画期的な成果である。
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