Epigenetic regulation of mTOR signalling pathway in placental nutrient transport.

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K08408
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: HIRANO Takeshi 北海道医療大学, 薬学部, 教授 (00322826)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: mTOR / エピジェネティック / 栄養 / 胎盤 / 母体 / 胎児 / トランスポーター / 輸送

Outline of Final Research Achievements

The mammalian target of rapamycin (mTOR) signaling pathways control protein synthesis in response to nutrient availability. Moreover, mTOR is a positive regulator of placental nutrient transport and is involved in the regulation of fetal growth. We focus on the role of mTOR in placental development, nutrient regulation and response.

Free Research Field

医療薬学

Academic Significance and Societal Importance of the Research Achievements

精密にプログラムされた一連の遺伝子発現と子宮内で極めて速い速度で発育・発達を続けている胎児の健やかな誕生に多大な貞献をもたらす。妊娠初期における栄養素の欠如は胎児にとって致命的であり、エピジェネティックな変化も含めた研究意義は極めて大きい。