Identification of interrelationships between hypoxia in tumor and biological clock for chronotherapy

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K08532
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Aichi Medical University
• Principal Investigator: Masubuchi Satoru 愛知医科大学, 医学部, 教授 (80362771)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: circadian / sleep / hypoxia

Outline of Final Research Achievements

To know relationships between tumor hypoxia and behavior rhythm of host, mice were exposed to hypoxia of different timings in a day. The largest response were observed by daytime hypoxia (DHx). DHx reduced activity of active phase and increased activity ending phase. This biphasic response was occurred by overlap between active phase and clock gene independent wave like response by DHx. In addition, this biphasic response was involved in sleep substance increased by DHx. And, another factor increased by DHx acted against the effect of DHx.

Free Research Field

時間生物学

Academic Significance and Societal Importance of the Research Achievements

休息期の低酸素により行動の2相性の変化、波様反応が起こることを初めて明らかにした。これは休息期の低酸素による病態（睡眠時無呼吸症候群、高山病の睡眠後の悪化）を理解するために有用である。特に治療抵抗性である睡眠時無呼吸症候群（Co-Morbid Insomnia and Sleep Apnea, COMISA)ではマウスの行動に対応した昼間の強い眠気と夜間の不眠が起こることから我々の研究結果から得られる示唆が多いと思われる。