2019 Fiscal Year Annual Research Report
Pathological analyses of the developmental mechanism and novel diagnostic and therapeutic methods in neuroendocrine mammary carcinomas
Project/Area Number |
16K08654
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Research Institution | Saitama Medical University |
Principal Investigator |
川崎 朋範 埼玉医科大学, 医学部, 教授 (90456484)
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Project Period (FY) |
2016-04-01 – 2020-03-31
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Keywords | 乳腺 / 神経内分泌癌 / 神経内分泌腫瘍 / 乳癌 / 特殊型 / 人体病理学 / 臨床細胞学 / 免疫組織化学 |
Outline of Annual Research Achievements |
1)乳腺神経内分泌癌(B-NEC)は、ホルモン療法や化学療法の感受性を伴って予後良好とみなされてきたが、非特殊型浸潤癌と比較し、侵攻性の臨床経過を示すことを示した (Pathol Int,2019 & 2016. ECP,2018-2020 & 2014. Histopathology,2013-2015, USCAP,2012 等)。 2)B-NEC の preinvasive counterpart として、我々は NE/solid papillary ductal carcinoma in situ の臨床・病理学的意義や生物学的特性を示してきたが (Histopathology,2008.Cytopathology,2012.Breast,2012.USCAP,2010 等)、その細胞学的特徴に関する分析・報告を行い、International Academy of Cytology の Best Poster Award を獲得した (ICC,2019 & ECP,2019)。 3)B-NEC の発生機構に関し、我々は背景乳腺組織に異型のない神経内分泌細胞がisolated/scattered pattern,clustered pattern,circumferential patternで広く分布する“Neuroendocrine cell hyperplasia”の概念を提唱、前癌病変としての意義を初めて示し(ECP,2019 & 2013.J Clin Pathol,2012.USCAP,2012 等)、類縁疾患である皮膚の endocrine mucin-producing sweat gland carcinoma(Pathol Int, 2012: 本邦で初)においても、その発生に同病態が関与しうることを初めて報告した (ECP,2019 & 2018.Pathology,2018 等)。 4)きわめて稀な乳腺 lymphoepithelioma-like carcinoma の細胞病理学的特徴を分析し、その診断学的意義およびピットフォール、治療効果・予後予測因子として注目されている TIL との密接な関連性について提示した (ICC,2019.Cytopathology,2017.ECP,2017 等)。
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[Journal Article] Role of Platelet C-Type Lectin-Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma2020
Author(s)
Jiro Ichikawa, Takashi Ando, Tomonori Kawasaki, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Yujiro Kimura, Kaoru Aoki, Keiko Hayakawa, Katsue Suzuki-Inoue, Masao Saitoh, Hirotaka Haro
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Journal Title
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume: in press
Pages: in press
DOI
Peer Reviewed
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[Journal Article] Severe hepatotoxicity due to osimertinib after nivolumab therapy in patients with non-small cell lung cancer harboring EGFR mutation2020
Author(s)
Ou Yamaguchi, Kyoichi Kaira, Tomonori Kawasaki, Atsuto Mouri, Kosuke Hashimoto, Ayako Shiono, Shun Shinomiya, Yu Miura, Fuyumi Nishihara, Yoshitake Murayama, Kunihiko Kobayashi, Satoshi Mochida, Hiroshi Kagamu
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Journal Title
Thoracic cancer
Volume: 11(4)
Pages: 1045-1051
DOI
Peer Reviewed
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[Journal Article] Invasive carcinoma with neuroendocrine differentiation of the breast showing triple negative, large and basal cell‐like features2019
Author(s)
Tomonori Kawasaki, Takahiro Hasebe, Mikinao Oiwa, Keiji Sugiyama, Chisako Muramatsu, Shigeto Ueda, Akihiko Osaki, Jiro Ichikawa, Norihiro Teramoto, Yoshihiko Hoshida
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Journal Title
Pathology International
Volume: 69
Pages: 502~504
DOI
Peer Reviewed
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[Journal Article] Methotrexate-associated Lymphoproliferative Disorders of T-cell Phenotype: Clinicopathological Analysis of 28 Cases2019
Author(s)
Akira Satou, Tetsuya Tabata, Hiroaki Miyoshi, Kei Kohno, Yuka Suzuki, Daisuke Yamashita, Kazuyuki Shimada, Tomonori Kawasaki, Yasuharu Sato, Tadashi Yoshino, Koichi Ohshima, Taishi Takahara, Toyonori Tsuzuki, Shigeo Nakamura
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Journal Title
Modern Pathology
Volume: 32(8)
Pages: 1135-1146
DOI
Peer Reviewed
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[Presentation] Neuroendocrine neoplasms of the breast showing peculiar forms of recurrence and/or metastasis2020
Author(s)
Tomonori Kawasaki, Anna Sapino, Motoo Ishida, Takashi Tada, Hideki Matsuya, Hiroshi Nakagomi, Toshio Oyama, Chisako Muramatsu, Jiro Ichikawa, Masao Saitoh, Tetsuo Kondo, Ryohei Katoh, Tamotsu Sugai, Yasuhiro Nakamura and Kyoichi Kaira
Organizer
32nd Congress of the European Society of Pathology and XXXIII International Congress of the International Academy of Pathology
Int'l Joint Research
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[Presentation] Neuroendocrine tumor of the breast with pulmonary metastasis 30 years after mastectomy2020
Author(s)
Tomonori Kawasaki, Ryo Taguchi, Hironori Ishida, Yuki Ichinose, Asami Nukui, Kazuo Matsuura, Takahiro Hasebe, Takashi Hojo, Akihiko Osaki, Yasuhiro Nakamura, Tetsuo Kondo, Kousuke Hashimoto, Ou Yamaguchi, Kyoichi Kaira, Hiroshi Kagamu and Toshiaki Saeki
Organizer
32nd Congress of the European Society of Pathology and XXXIII International Congress of the International Academy of Pathology
Int'l Joint Research
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[Presentation] Invasive carcinoma with neuroendocrine differentiation of the breast showing triple negative, large and basal cell-like features2019
Author(s)
Tomonori Kawasaki, Norihiro Teramoto, Yoshihiko Hoshida, Yuya Murata, Keiji Sugiyama, Mikinao Oiwa, Chisako Muramatsu, Jiro Ichikawa, Ikuko Sugitani, Shigeto Ueda, Takahiro Hasebe, Akihiko Osaki, Kyoichi Kaira
Organizer
31st European Congress of Pathology
Int'l Joint Research
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[Presentation] High-molecular-weight insulin-like growth factor 2 secreting phyllodes tumor of the breast presenting as a hypoglycemic attack2019
Author(s)
Tomonori Kawasaki, Shigeto Ueda, Yuki Ichinose, Eiko Hirokawa, Hiroko Shimada, Ikuko Sugitani, Hiroshi Sano, Takahiro Hasebe, Takao Takahashi, Akihiko Osaki, Toshiaki Saeki, Yoichi Oikawa, Ikuo Inoue, Mitsuhiko Noda, Akira Shimada, Yoji Nagashima, Makoto Urano, Makoto Kuroda, Toshiaki Utsumi, Takanori Hayashi
Organizer
31st European Congress of Pathology
Int'l Joint Research
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[Presentation] Well-differentiated neuroendocrine tumor of the breast with recurrence due to needle tract seeding2019
Author(s)
Tomonori Kawasaki, Motoo Ishida, Takashi Tada, Hideki Matsuya, Norihiro Teramoto, Yoshihiko Hoshida, Yuya Murata, Masahiro Ito, Kazuya Kuraoka, Kumi Aita, Ryoko Sugiura, Hitomi Kodama, Takahiro Hasebe, Takashi Hojo, Akihiko Osaki and Toshiaki Saeki
Organizer
第50回埼玉群馬乳腺疾患研究会
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[Presentation] Follicular lymphoma of the male breast2019
Author(s)
川崎朋範, 佐野弘, 上田重人, 杉谷郁子, 島田浩子, 廣川詠子, 近藤奈美, 長谷部孝裕, 大崎昭彦, 高橋孝郎, 鎌田孝一, 伊藤梢絵, 佐藤次生, 新井栄一, 田丸淳一, 塚崎邦弘, 高橋直樹, 市川二郎, 齋藤正夫, 佐伯俊昭
Organizer
第27回日本乳癌学会学術総会
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[Presentation] ワークショップ 『癌の悪性度を規定する因子-癌微小環境および脈管内腫瘍塞栓の役割』 癌間質と腫瘍内マクロファージの密接な関係について2019
Author(s)
島田浩子, 長谷部孝裕, 杉山迪子, 杉谷郁子, 淺野彩, 佐野弘, 近藤奈美, 上田重人, 川崎朋範, 大崎昭彦, 佐伯俊昭
Organizer
第27回日本乳癌学会学術総会
Invited
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[Presentation] SMARCA4‐deficient thoracic sarcomaの一例2019
Author(s)
浜田芽衣, 加藤智美, 扇田智彦, 目黒葉子, 永田耕治, 佐藤次生, 佐藤奈帆子, 川崎朋範, 新井栄一, 長塚仁, 安田政実
Organizer
第58回日本臨床細胞学会秋期大会 岡山
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[Presentation] 耳前部に発生した胞巣状軟部肉腫(ASPS)の一例2019
Author(s)
加藤智美, 浜田芽衣, 扇田智彦, 目黒葉子, 鎌倉靖夫, 菅野恵士, 川崎朋範, 井上準, 中平光彦, 矢澤康男, 安田政実
Organizer
第58回日本臨床細胞学会秋期大会 岡山
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