Investigation for oncogenesis in IgG4-related disease

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K08666
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Okayama University
• Principal Investigator: Yausharu Sato 岡山大学, 保健学研究科, 教授 (00579831)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: IgG4-related disease

Outline of Final Research Achievements

IgG4-RD is a systemic disorder involving benign mass formation due to fibrosis and intense lymphoplasmacytosis; the chronic inflammation associated with the disease might also contribute to oncogenesis. AID is overexpressed in various cancers and may be important in chronic inflammation-associated oncogenesis. We examined AID expression in IgG4-related sialadenitis and controls using immunohistochemistry and qPCR. Immunohistochemistry revealed significantly more AID-expressing cells in IgG4-related sialadenitis than in sialolithiasis or normal submandibular gland samples; qPCR yielded similar results. Thus, AID was significantly more up-regulated and had higher expression in extra-germinal centres in IgG4-RD than in non-specific inflammation or normal conditions. This report suggests that IgG4-RD has several specific causes of AID up-regulation in addition to inflammation. Furthermore, chronic inflammation-associated AID-mediated oncogenesis is possible in IgG4-RD.

Free Research Field

病理学

Academic Significance and Societal Importance of the Research Achievements

IgG4関連疾患は全身性に腫瘤や肥厚性病変を形成する炎症性疾患であるが、統計学的に悪性腫瘍を発症する頻度が高いことが統計学的に報告されている。そこでIgG4観点疾患における発がん蛋白について検索した。その結果、IgG4関連疾患においてAIDという発がん関連蛋白が高発現していることが今回の研究で明らかになった。今後は、発がん予防の目的で、このAIDを標的とした治療法への開発の糸口になり得る可能性が示唆された。