Protective Effects of Peroxiredoxin 4 (PRDX4) on Metabolic Syndrome

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K08750
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kanazawa Medical University (2017-2018); Kagoshima University (2016)
• Principal Investigator: YAMADA Sohsuke 金沢医科大学, 医学部, 教授 (90525453)
• Research Collaborator: TANIMOTO Akihide
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 抗酸化ストレス因子 / PRDX4 / メタボリックシンドローム / 予防

Outline of Final Research Achievements

The peroxiredoxin (PRDX) 4 is the only known secretory form and protects against oxidative damage by scavenging reactive oxygen species in both the intracellular compartments and the extracellular space. We generated unique human PRDX4 (hPRDX4) transgenic (Tg) mice and investigated the critical/diverse protective roles of PRDX4 against diabetes mellitus, atherosclerosis, insulin resistance, and nonalcoholic fatty liver disease (NAFLD) as well as evaluated its role in the intestinal function in various animal models. Our published data have shown that PRDX4 helps prevent the progression of metabolic syndrome by reducing local and systemic oxidative stress and synergistically suppressing steatosis, inflammatory reactions, and/or apoptotic activity. These observations suggest that Tg mice may be a useful animal model for studying the relevance of oxidative stress on inflammation and the dysregulation of lipid/bile acid/glucose metabolism upon the progression of human metabolic syndrome.

Free Research Field

メタボリックシンドローム

Academic Significance and Societal Importance of the Research Achievements

我々のグループでは、ヒトPRDX4 (hPRDX4)のトランスジェニックマウス(Tg)を独自に作製し、PRDX4が酸化ストレスおよび炎症性サイトカイン、アポトーシスを抑制し、メタボリックシンドローム回避に傾かせしめ得ることを解明してきた。これらの研究成果により、PRDX4の特殊性、特異性を際立たせることが可能となった。
これら我々の包括的な基礎研究が、将来的に臨床応用にまで結びつけば、非常に有意な独創性・社会的意義を持っていると確信される。