2018 Fiscal Year Final Research Report
Investigation of revolutionary predictive biomarkers for structural damage and risk of flare after withdrawal of drugs due to remission in rheumatoid arthritis
| Project/Area Number |
16K08956
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 関節リウマチ / バイオマーカー |
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| Outline of Final Research Achievements |
MBDA, 14-3-3η and collagen degeneration products were identified as useful biomarkers to predict or detect the risk of structural damage in patients with rheumatoid arthritis (RA). As well, type III collagen degenerated products by MMPs (C3M) and type III pro-collagen (ProC3) were identified as new biomarkers for fibrogenesis in RA, through investigating various possible biomarkers including cytokines, cytokine receptors, adhesion molecules, proteinases, and metabolic markers. These results were presented at international or domestic scientific meetings and published on international journals.
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| Free Research Field |
膠原病・アレルギー内科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、本邦では未だ臨床適用されていない新たなバイオマーカーとして、MBDAスコア、14-3-3η、コラーゲン代謝産物の日本人RA患者における可能性を初めて明らかにした。これらの新規バイオマーカーはRA病態の詳細な理解に繋がり、かつ将来わずかな血液で簡便かつ客観的に病態把握が可能となる端緒となりうる。またRAの適切な治療選択および寛解休薬の導入に貢献しprecision medicineの実現に役立つ可能性が示された。
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