2023 Fiscal Year Final Research Report
Elderly patients with cardiovascular disease are associated with frailty
| Project/Area Number |
16K09042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2024-03-31
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| Keywords | フレイル / 心不全 / 虚血性心疾患 / 転倒 / 長期予後 |
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| Outline of Final Research Achievements |
The prevalence of physical frailty among elderly patients attending outpatient clinics was higher than that among community-dwelling elderly people, especially among patients with coronary artery disease and heart failure. Compared with the non-frail group, the frail group was more likely to be older, have a lower BMI, have lower cognitive function, osteoporosis, and a history of stroke/myocardial infarction/heart failure/malignancy/diabetes. Multivariate analysis showed that heart failure and myocardial infarction were associated with an increased risk of frailty. On the other hand, the progression of frailty due to heart failure or a history of myocardial infarction tended to be suppressed if the level of activity in daily life was high.
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| Free Research Field |
循環器
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| Academic Significance and Societal Importance of the Research Achievements |
フレイル評価は現在日常臨床で評価されていないが、循環器疾患だけではなく内科疾患で通院している患者では同年代の地域住民と比べ、高いことが実証されたことやフレイルは転倒の予測因子であることが明らかになり、転倒は日常生活の質の低下や死亡と関連していることから日常臨床でのフレイル評価を実施する臨床的意義は極めて高いと考えられる。また、日常生活での運動療法もフレイルへの進展を抑制に関与することが示唆されたことから、高齢者への日常生活での歩行運動の寝たきり予防への普及への社会的アピールに繋がると考えられる。
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