Prospective study on exposure to tobacco smoke early in life and allergic diseases

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09128
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Gifu University
• Principal Investigator: Keiko Wada 岐阜大学, 大学院医学系研究科, 准教授 (00532673)
• Co-Investigator(Renkei-kenkyūsha): Nagata Chisato 岐阜大学, 大学院医学系研究科, 教授 (30283295)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 受動喫煙 / アレルギー / 胎児期 / 小児期 / 疫学

Outline of Final Research Achievements

We conducted an epidemiologic study on risks of allergy diseases in relation to exposure to tobacco smoke early in life. Exposure to tobacco smoke in fetal period, assessed by urinary cotinine levels in pregnant mothers, was not significantly associated with any of immunoglobulin E levels in cord blood and asthma, atopic dermatitis, and allergic rhinitis in childhood. Among young children, smoking habits of parents and other family members were not significantly associated with any of asthma, atopic dermatitis, and allergic rhinitis. Also, there were no significant associations between urinary cotinine levels and these allergic diseases.

Free Research Field

疫学

Academic Significance and Societal Importance of the Research Achievements

本研究では、胎児期、幼児期のたばこ煙曝露と気管支喘息、アトピー性皮膚炎、アレルギー性鼻炎のリスクとの間に有意な関連はみられなかったが、出生前後や幼少期にたばこ煙に暴露されることが、将来の健康や病気の罹患にどのような影響を与えるかはいまだよくわかっていないので、今後も研究が必要である。