2018 Fiscal Year Final Research Report
Investigation of the molecular foundation reducing a natural immunity caused by chronic stress
| Project/Area Number |
16K09271
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
General internal medicine(including psychosomatic medicine)
|
|---|
| Research Institution | Kindai University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-10-21 – 2019-03-31
|
| Keywords | 慢性ストレス / 自然免疫 / 自律神経 / 肺胞マクロファージ / 貪食 |
|---|
| Outline of Final Research Achievements |
We investigated the effect that chronic stress condition gave for natural immunity. As a result, we obtained the following findings.
(1) The chronic stress reduces a phagocytic activity of the alveolar macrophage and a production of inflammatory cytokine. (2) Sympathetic hypotonia is involved in a decrease of the phagocytic activity in the alveolar macrophage. (3) The phagocytic activity decrease of the chronic stress-induced alveolar macrophage is improved by a beta 2 receptor stimulant drug.These results suggest that the chronic stress reduces natural immunity through a beta 2 receptor.
|
| Free Research Field |
生化学・薬理学
|
| Academic Significance and Societal Importance of the Research Achievements |
この研究から，慢性ストレスにより破綻した自律神経系を介して自然免疫系に重要な役割を果たしている肺胞マクロファージの機能低下を誘発し，ストレスにより発症及び憎悪する一因に免疫力の低下が様々な疾患に関与している可能性が明らかとなった。また，このメカニズムの一端を解明したことでストレス関連症状の発症や悪化した症状を抑制し，患者のQOLを向上させる一つの手段となり得ることが期待できる。
|
