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2019 Fiscal Year Annual Research Report

establishment of POEM for esophageal motility disorders

Research Project

Project/Area Number 16K09291
Research InstitutionShowa University

Principal Investigator

井上 晴洋  昭和大学, 医学部, 教授 (90280966)

Project Period (FY) 2016-04-01 – 2020-03-31
Keywordsアカラシア / POEM(経口内視鏡的筋層切開術) / びまん性食道攣縮 / Nutcracker食道 / Jack-Hammer食道 / 食道運動機能障害 / 先天性食道狭窄
Outline of Annual Research Achievements

POEMは、当院だけでも現在2100例以上の症例に施行している。成功率は97%以上であった。POEMは、日本消化器内視鏡学会のガイドラインとして、和文、英文で発表した(Inoue H et al. Dig Endosc 2018; 30: 563-79)。またPOEMの3000例以上の全国調査も米国の主要学術雑誌に報告した(Shiwaku H et al. GIE2019. pii: S0016-5107(19)32470-8.)。さらにPOEMの進化した手技としてPOEM+Fを発表した(Inoue H et al. Endoscopy 2019; 51: 161-4)。POEM+Fは、口から挿入した内視鏡を粘膜下層を介して、腹腔内に入り、噴門形成術をおこなう術式である。これまでに30例以上におこなっていて良好な成績である。

  • Research Products

    (18 results)

All 2020 2019

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 1 results) Presentation (3 results) Book (2 results)

  • [Journal Article] Multicenter collaborative retrospective evaluation of peroral endoscopic myotomy for esophageal achalasia: analysis of data from more than 1300 patients at eight facilities in Japan2020

    • Author(s)
      Shiwaku H, Inoue H, Onimaru M, Minami H, Sato H, Sato C, Tanaka S, Ogawa R, Okushima N
    • Journal Title

      Surgical Endoscopy

      Volume: 34 Pages: 464-468

    • Peer Reviewed
  • [Journal Article] Clinical outcomes of per‐oral endoscopic tumor resection for submucosal tumors in the esophagus and gastric cardia2020

    • Author(s)
      Onimaru Manabu、Inoue Haruhiro、Bechara Robert、Tanabe Mayo、Abad Mary Raina Angeli、Ueno Akiko、Shimamura Yuto、Sumi Kazuya、Ikeda Haruo、Ito Hiroaki
    • Journal Title

      Digestive Endoscopy

      Volume: 32 Pages: 328~336

    • DOI

      10.1111/den.13471

    • Peer Reviewed
  • [Journal Article] Gastroesophageal reflux disease after peroral endoscopic myotomy: lest we forget what we already know2020

    • Author(s)
      Bechara Robert、Inoue Haruhiro、Shimamura Yuto、Reed David
    • Journal Title

      Diseases of the Esophagus

      Volume: 32 Pages: 1-7

    • DOI

      10.1093/dote/doz106

    • Peer Reviewed
  • [Journal Article] Peroral endoscopic myotomy for achalasia: a prospective multicenter study in Japan2020

    • Author(s)
      Shiwaku Hironari、Inoue Haruhiro、Sato Hiroki、Onimaru Manabu、Minami Hitomi、Tanaka Shinwa、Sato Chiaki、Ogawa Ryo、Okushima Norihiko、Yokomichi Hiroshi
    • Journal Title

      Gastrointestinal Endoscopy

      Volume: 91 Pages: 1037-1044

    • DOI

      10.1016/j.gie.2019.11.020

    • Peer Reviewed
  • [Journal Article] POEM as salvage therapy in patients with achalasia refractory to endoscopic or surgical therapy is technically feasible and safe: A systematic review and meta‐analysis2020

    • Author(s)
      Hashimoto Rintaro、Inoue Haruhiro、Shimamura Yuto、Sakuraba Atsushi、Tomizawa Yutaka
    • Journal Title

      Digestive Endoscopy

      Volume: - Pages: -

    • DOI

      10.1111/den.13643

    • Peer Reviewed
  • [Journal Article] Statement for gastroesophageal reflux disease after peroral endoscopic myotomy from an international multicenter experience.2020

    • Author(s)
      Inoue H, Shiwaku H, Kobayashi Y, Chiu PWY, Hawes RH, Neuhaus H, Costamagna G, Stavropoulos SN, Fukami N, Seewald S, Onimaru M, Minami H, Tanaka S, Shimamura Y, Santi EG, Grimes K, Tajiri H.
    • Journal Title

      Esophagus

      Volume: 17 Pages: 3-10

    • DOI

      10.1007/s10388-019-00689-6

    • Peer Reviewed / Open Access
  • [Journal Article] Peroral endoscopic myotomy and fundoplication: a novel NOTES procedure2019

    • Author(s)
      Inoue Haruhiro、Ueno Akiko、Shimamura Yuto、Manolakis Anastassios、Sharma Ashish、Kono Shin、Nishimoto Masayuki、Sumi Kazuya、Ikeda Haruo、Goda Kenichi、Onimaru Manabu、Yamaguchi Noriko、Itoh Hiroaki
    • Journal Title

      Endoscopy

      Volume: 51 Pages: 161~164

    • DOI

      10.1055/a-0820-2731

    • Peer Reviewed
  • [Journal Article] Anterior versus posterior myotomy during POEM for the treatment of achalasia: systematic review and meta-analysis of randomized clinical trials2019

    • Author(s)
      Rodríguez de Santiago E, Mohammed N, Manolakis A, Shimamura Y, Onimaru M, Inoue H
    • Journal Title

      Journal of Gastrointestinal and Liver Diseases

      Volume: 28 Pages: 107-115

    • DOI

      10.15403/jgld.2014.1121.281.pom

    • Peer Reviewed
  • [Journal Article] 2007-2019: a "Third"-Space Odyssey in the Endoscopic Management of Gastrointestinal Tract Diseases2019

    • Author(s)
      Manolakis AC, Inoue H, Ueno A, Shimamura Y
    • Journal Title

      Curr Treat Options Gastroentero

      Volume: 17 Pages: 202-220

    • Peer Reviewed
  • [Journal Article] Multicenter Evaluation of Clinical Efficacy and Safety of Per-oral Endoscopic Myotomy in Children2019

    • Author(s)
      Choné A, Familiari P, von Rahden B, Desai P, Inoue H, Shimamura Y, Eleftheriadis N, Yamashita K, Khashab MA, Shiwaku H, Seewald S, e.t.c
    • Journal Title

      Journal of Pediatric Gastroenterology and Nutrition

      Volume: 69 Pages: 523~527

    • DOI

      10.1097/MPG.0000000000002432

    • Peer Reviewed
  • [Journal Article] Identification of human herpes virus 1 encoded micro RNAs in biopsy samples of lower esophageal sphincter muscle during per-oral endoscopic myotomy for esophageal achalasia2019

    • Author(s)
      Ikebuchi Yuichiro、Kanda Tsutomu、Ikeda Haruo、Yoshida Akira、Sakaguchi Takuki、Urabe Shigetoshi、Minami Hitomi、Nakao Kazuhiko、Kuwamoto Satoshi、Inoue Haruhiro、Isomoto Hajime
    • Journal Title

      Digestive Endoscopy

      Volume: 32 Pages: 136~142

    • DOI

      10.1111/den.13491

    • Peer Reviewed
  • [Journal Article] Gastric myotomy length affects severity but not rate of post-procedure reflux: 3-year follow-up of a prospective randomized controlled trial of double-scope per-oral endoscopic myotomy (POEM) for esophageal achalasia2019

    • Author(s)
      Grimes KL, Bechara R, Shimamura Y, Ikeda H, Inoue H
    • Journal Title

      Surgical Endoscopy

      Volume: - Pages: -

    • Peer Reviewed
  • [Journal Article] Peroral endoscopic myotomy (POEM) opens the door of third-space endoscopy2019

    • Author(s)
      Inoue Haruhiro、Maydeo Amit
    • Journal Title

      Endoscopy

      Volume: 51 Pages: 1010~1012

    • DOI

      10.1055/a-1019-1865

    • Peer Reviewed
  • [Presentation] 食道良性疾患に対する新しい内視鏡診断と治療2019

    • Author(s)
      井上晴洋
    • Organizer
      第73回日本食道学会学術集会
  • [Presentation] The 10th anniversary of POEM development2019

    • Author(s)
      井上晴洋
    • Organizer
      第96回日本消化器内視鏡学会総会
  • [Presentation] 食道良性疾患に対する新しい内視鏡診断と治療2019

    • Author(s)
      井上晴洋
    • Organizer
      第111回日本消化器病学会中国支部例会
  • [Book] 医学のあゆみ2020

    • Author(s)
      井上晴洋
    • Total Pages
      4
    • Publisher
      医歯薬出版(株)
  • [Book] 月刊消化器内科2020

    • Author(s)
      井上晴洋
    • Total Pages
      1
    • Publisher
      医学出版

URL: 

Published: 2021-01-27  

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