Elucidation of pathophysiology of inflammatory bowel disease focusing on fatty acid metabolism enzyme SCD1

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09308
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Shiga University of Medical Science
• Principal Investigator: INATOMI OSAMU 滋賀医科大学, 医学部, 講師 (70530351)
• Co-Investigator(Kenkyū-buntansha): 馬場 重樹 滋賀医科大学, 医学部, 講師 (40422901)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: SCD-1

Outline of Final Research Achievements

It was suggested that SCD-1 in the mucosal area plays an important role in the cause of exacerbation of colitis due to high fat diet. In DSS colitis, LC3 expression in colonic epithelium was significantly increased as compared to control mice, and the action was further enhanced by the administration of chloroquine. Administration of a high-fat diet did not enhance LC3 expression, and accumulation of the selective autophagy substrate p62 was observed. This indicates that high fat diet load may cause autophagy failure for some reason, and may cause deterioration of enteritis.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

高脂肪食がクローン病を増悪させるメカニズムは長らく解明されていないが、本研究では脂肪酸代謝に関わるSCD-1とオートファージーを介した腸管局所での炎症進展機序の重要性を明らかにした。