Impact of low-carbohydrate diet on the gut microbiota and mucosal immunity

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09324
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kitasato University
• Principal Investigator: Kobayashi Taku 北里大学, 北里研究所病院, 副センター長 (10424144)
• Co-Investigator(Kenkyū-buntansha): 山田 悟 北里大学, 北里研究所病院, 部長(医師) (10286487)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 糖質制限

Outline of Final Research Achievements

In order to clarify the relationship between diet and enterobacteria and intestinal immunity, the following studies were conducted by roughly dividing into (I) mouse (II) human. Bacterial flora increased in Clostridium cluster XI, Lactobacillales, and Prevotella compared with NFD group when mice were fed a high-fat or carbohydrate-restricted diet, and Bacteroides decreased considerably. . By linking with a carbohydrate-restricted diet education program for diabetic patients to examine and confirm their significance in humans, intestinal microflora in Japanese diabetic patients, intestinal microflora changes by carbohydrate-restricted diet, carbohydrate-restricted diet Most of the effective and ineffective cases were examined for the presence or absence of intestinal flora change in the discontinued cases.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

糖質制限食はカロリーについての制限がないにも関わらず、急性期の効果としての血糖コントロール改善のみならず、肥満を改善する効果もあり、その有効性は広く認知され社会的に大きなブームとなっている。この糖質制限食の腸内細菌に対する影響、腸管免疫に対する影響を科学的に調べることは非常に重要と考える。