Multiple biomarkers in patients with chronic circuratory failure and multiorgan dysfunction

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09414
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: Tatebe Shunsuke 東北大学, 大学病院, 助教 (90456062)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: バイオマーカー / 成人先天性心疾患 / 慢性心不全 / 心血管予後 / HCV / MELD-XI / PR間隔 / Cyclophilin A

Outline of Final Research Achievements

The purpose of the present study was to evaluate multiple organ dysfunction and prognosis by multiple biomarkers and invasive hemodynamic methods in patients with chronic circulatory failure. We have reported plasma levels of cyclophilin A (CyPA) predicted cardiovascular prognosis in patients with coronary artery disease (CAD). We have also found that plasma CyPA as a useful biomarker for evaluation of the effects of balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. In the field of adult congenital heart disease (ACHD), we have reported (1) hepatitis C virus positivity adversely impacted cardiac function and long-term prognosis in patients undergoing heart surgery before 1992 and (2) ACHD patients with high MELD-XI (Model for End-Stage Liver Disease Excluding INR) score had poor cardiovascular outcomes, and (3) PR interval prolongation predicted cardiovascular prognosis in adults with repaired tetralogy of Fallot.

Free Research Field

循環器内科

Academic Significance and Societal Importance of the Research Achievements

慢性循環不全患者の遠隔期心血管合併症発症のリスク因子を後向き、前向き研究において複数同定した。各々の心疾患において、当該リスク因子を予後バイオマーカーとして計測・評価することで、ハイリスク患者の同定および患者予後の改善が期待される。さらに本研究は当該疾患の、診療ガイドライン策定にも資する臨床的エビデンスを提供した。新たな介入研究の標的候補としても、役立つものとおもわれる。