2019 Fiscal Year Final Research Report

Quantification of myocardial perfusion using a combination of bolus tracking and time-registered 320-row multi detector CT for patients with coronary artery disease

Research Project

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Project/Area Number	16K09461
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cardiovascular medicine
Research Institution	Fujita Health University
Principal Investigator	Sarai Masayoshi 藤田医科大学, 大学病院, 教授 (10298531)
Co-Investigator(Kenkyū-buntansha)	元山貞子藤田医科大学, 医学部, 教授 (30308902) 夏目貴弘藤田医科大学, 保健学研究科, 准教授 (30597604) 尾崎行男藤田医科大学, 医学部, 教授 (50298569) 外山宏藤田医科大学, 医学部, 教授 (90247643) 市原隆藤田医科大学, 医学部, 教授 (90527748)
Project Period (FY)	2016-04-01 – 2020-03-31
Keywords	心筋血流 / 核医学 / CT
Outline of Final Research Achievements	The purpose of this study is to compare the three calculation methods of MBF quantification by dynamic CT perfusion imaging during ATP infusion. A total of 7 cases were examined including 3 normal, 2 SVD, 1 TVD and 1 OMI. All images were assessed in 17 segments. The MBF (ml/min/g) of each were compared with SPECT data. The relationship between MBF-CT and % uptake-SPECT during stress showed significant correlation in one-shot scan (P<.0001) and clearance phase (P<.0001). The relationship between MBF-CT and % uptake-SPECT at rest showed significant correlation in one-shot scan (P=.0021) and clearance phase (P=.0002). In SVD, the relationship between MBF-CT and % uptake-SPECT during stress showed significant correlation. It is considered that MBF quantification calculated from one-shot scan and clearance phase of TAC are appropriate value by dynamic CT perfusion imaging during ATP infusion.
Free Research Field	心臓核医学
Academic Significance and Societal Importance of the Research Achievements	臨床では狭心症の評価を相対的な心筋血流評価法で行っているが、重症虚血を見落とす可能性がある。今回、臨床で使用している造影CTで絶対的な心筋血流を評価することが可能となり、より安全で正確な狭心症評価が可能となった。