Relationship between DOAC and vascular endotherial function in patient with atrial fibrillation

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09466
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kawasaki Medical School
• Principal Investigator: Imai Koichiro 川崎医科大学, 医学部, 講師 (90388942)
• Co-Investigator(Kenkyū-buntansha): 古山 輝將 川崎医科大学, 医学部, 講師 (20434996) ; 玉田 智子 川崎医科大学, 医学部, 講師 (90435016)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 内皮機能 / エンドパッド / 心房細動 / アブレーション

Outline of Final Research Achievements

Before ablation, vascular endothelial function was measured using an end pat and also measured at follow-up. In general, vascular endothelial function (RHI) is the observation item and the criteria　Values: 2.10 or more Good, 1.68 to 2.09 No problem, 1.67 or less It is judged that it needs attention.
The RHI before ablation was 1.93, and after ablation, it showed a tendency of improvement of 2.2, and there was no statistically significant difference. However, RHI was good before ablation. The number of cases is small, and it is necessary to consider as limitation because it is a test that is often measured at the time of out-patient and susceptible to environmental changes during Follow-up, but it is necessary to consider it as a blood vessel by atrial fibrillation patient Endothelial function improvement effect was not found in this study。

Free Research Field

循環器学

Academic Significance and Societal Importance of the Research Achievements

今回の研究ではアブレーションにおける内皮機能障害の改善は見いだせなかった。