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2018 Fiscal Year Final Research Report

Role of senescent cell removal mechanism in the pathogenesis of idiopathic pulmonary fibrosis

Research Project

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Project/Area Number 16K09591
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionJikei University School of Medicine

Principal Investigator

Haruhiko Yanagisawa  東京慈恵会医科大学, 医学部, 助教 (00773425)

Co-Investigator(Kenkyū-buntansha) 桑野 和善  東京慈恵会医科大学, 医学部, 教授 (40205266)
原 弘道  東京慈恵会医科大学, 医学部, 講師 (70398791)
Project Period (FY) 2016-04-01 – 2019-03-31
KeywordsIPF / 線維化 / 細胞老化
Outline of Final Research Achievements

Several lines of evidence suggest that epithelial cells are senescent in Idiopathic Pulmonary Fibrosis (IPF). To elucidate the role of epithelial cell senescence in lung fibrosis, we used mouse model of radiation-induced lung fibrosis.
Radiation to mouse lung induced cellular senescence in bronchial epithelial cells. Elimination of senescent bronchial epithelial cells by naphthalene inhibited radiation-induced lung fibrosis. Bronchial epithelial cell senescence may play important roles in the pathogenesis of radiation-induced lung fibrosis.

Free Research Field

呼吸器内科

Academic Significance and Societal Importance of the Research Achievements

IPFは進行性の疾患で、診断されてから生存期間中央値は約3年とする報告や、5年生存率は20~40%と示されており非常に予後が不良である。老化関連呼吸器疾患の一つであり、肺組織では老化上皮細胞が増加している。種々のサイトカインを産生し病態を悪化させる。
IPF における老化上皮細胞の除去機構を解明し、制御することができれば、IPFの病態を改善できる可能性がある。

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Published: 2020-03-30  

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