• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2018 Fiscal Year Final Research Report

Tumor associated Neutrophils control NSCLC-Immune interface

Research Project

  • PDF
Project/Area Number 16K09597
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionMiyagi Prefectural Hospital Organization Miyagi Cancer Center

Principal Investigator

FUKUHARA TATSURO  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員 (80400365)

Co-Investigator(Kenkyū-buntansha) 前門戸 任  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員 (40344676)
田中 伸幸  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 部長 (60280872)
長島 隆一  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 研究技師 (20783707)
Project Period (FY) 2016-04-01 – 2019-03-31
Keywords非小細胞肺がん / 好中球
Outline of Final Research Achievements

NSCLC is one of the most common cancer worldwide and therapy-resistance awaits further improvement. We found that syngeneic lung tumor includes a Neutrophil population. To study a role of tumor associated Neutrophil (TAN), we depleted Neutrophil in vivo. Neutrophil depletion decreased tumor size, which prompted us to screen for a factor that recruits Neutrophils into NSCLC. We identified S100A proteins are abundantly expressed in NSCLC. S100A protein expressions were induced in response to EGF. Because former reports suggested their potential ability to recruit Neutrophils, S100A may be a good marker for NSCLC as well as a potential therapeutic targets.

Free Research Field

呼吸器腫瘍学

Academic Significance and Societal Importance of the Research Achievements

非小細胞肺癌における腫瘍内好中球の意義を見出したことが学術的意義がある。新たな肺癌マーカー遺伝子を発見した点で社会的意義がある。肺癌の治療標的としての可能性があり発展すれば、社会貢献となることが期待される。

URL: 

Published: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi