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2018 Fiscal Year Final Research Report

Study of nerve terminal attraction and neuroprotective effect by Schwann cells on diabetic polyneuropathy

Research Project

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Project/Area Number 16K09768
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionAichi Medical University

Principal Investigator

Nakamura Jiro  愛知医科大学, 医学部, 教授 (40283444)

Co-Investigator(Kenkyū-buntansha) 加藤 宏一  愛知学院大学, 薬学部, 教授 (40319322)
姫野 龍仁  愛知医科大学, 医学部, 講師 (60753762)
神谷 英紀  愛知医科大学, 医学部, 准教授 (70542679)
Research Collaborator Kondo Masaki  
Miura-Yura Emiri  
Project Period (FY) 2016-04-01 – 2019-03-31
Keywords糖尿病性神経障害 / 細胞移植療法 / 幹細胞 / サイトカイン / 血管再生
Outline of Final Research Achievements

Improvement of nerve conduction velocity and regeneration of small blood vessels at the transplantation site were confirmed as therapeutic effects in diabetic polyneuropathy (DPN) using skin-derived neural crest stem cell transplantation. It was suggested that differentiation of cytokines secreted from stem cells (PGE2, NGF) and stem cells engrafted at the transplanted site into vascular component cells plays a DPN therapeutic effect.
In secretory factors derived from DPSC (dental pulp stem cells), the neurite outgrowth effect on the peripheral nervous system was confirmed in mouse dorsal root ganglion cells. It was suggested that VEGF is involved in the mechanism of action. Furthermore, in vivo, it was suggested that low molecular weight proteins other than cytokines exert therapeutic effects in DPSC secretion factor.

Free Research Field

代謝

Academic Significance and Societal Importance of the Research Achievements

今回の成果により糖尿病神経障害の新たな治療法と末梢神経における合併症の発症機転に幹細胞の欠如が関係する可能性が示唆された。今後の糖尿病合併症治療に幹細胞移植療法または、幹細胞から産生されるの液性因子が補充されることで、合併症の進行を止めるだけでなく完治に向けた治療法の確立が可能となることが期待される。社会的な貢献としては、糖尿病合併症の重症化でADLの低下した患者の社会復帰を支援、補完する可能性もある。そのために、できる限り早期の幹細胞移植療法の実現に向けて更なる科学的根拠を積み上げていく所存である。

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Published: 2020-03-30   Modified: 2021-02-19  

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