Effects of diabetes-related lipid dysregulation in astrocytes on cognitive functions

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09776
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Tokyo Medical University (2018); The University of Tokyo (2016-2017)
• Principal Investigator: Suzuki Ryo 東京医科大学, 医学部, 准教授 (20396732)
• Research Collaborator: Chou Shengpu ; Watanabe Ryusuke ; Terai Ai ; Kamei Nozomu ; Kadowaki Takashi
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 糖尿病 / 脳脂質代謝 / コレステロール合成 / SCAP / AMPK

Outline of Final Research Achievements

Brain from a subject with diabetes mellitus exhibits elevated activity of AMPK and reduction of SCAP. AMPK signaling potentially promotes transport of SCAP-SREBP complex from ER to Golgi via Rab2 pathway. Reduction of SCAP in astrocytes can inhibit growth and maturation of adjacent neurons.

Free Research Field

糖尿病

Academic Significance and Societal Importance of the Research Achievements

糖尿病が認知機能を低下させるメカニズムは未だ不明な点が多い。アストロサイトにおけるエネルギー状態と脂質代謝の変化によってニューロンの成熟状態が影響を受ける新規分子経路を提唱する結果である。