Pathophysiological involvement of brain fractalkine-CX3CR1 signal in obesity

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09788
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kagoshima University
• Principal Investigator: Katsuura Goro 鹿児島大学, 医歯学総合研究科, 特任研究員 (20401226)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 肥満 / マイクログリア / fractalkine / CX3CR1 / 摂食調節 / 学習記憶

Outline of Final Research Achievements

Fractalkine-CX3CR1 signal plays an importatnt role in regulation of activities of the central nervous sytem. In the present study, the effects of fractalkine on food intake in mice were observed. The following results were obtained; (1) The mRNA expressions of fractalkineマイクログリアractalkine and CX3CR1 in the　hypothalamus　were　significantly　decreased　after　48-hr　fasting,　and　then　returned　to normal levels. The intracerevrobentricular (icv) administration of fractalkine significantly decreased food intake of refeeding.(2) The icv administration of fractalkine significantly deceased food intake of noctarnal phase. (3) The icv administration of fractalkine significantly deceased food intake induced by ghrelin and neuropeptide Y. These findings suggest that fractalkine-CX3CR1 signal has anorexigenic actions in mice.

Free Research Field

神経薬理

Academic Significance and Societal Importance of the Research Achievements

肥満病態での中枢神経系のエネルギー調節機能について、神経細胞とマイクログリアの相互作用を明らかにすることによって、肥満に関連する機能異常のメカニズムを明らかにし、さらに、新規治療薬の開発にとっての基盤的情報を得ることができた。