The novel mechanism of KCNJ5 transgenic mice.

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K09794
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Gunma University
• Principal Investigator: Nakajima Yasuyo 群馬大学, 医学部附属病院, 助教 (70707017)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 原発性アルドステロン症 / 疾患モデル動物

Outline of Final Research Achievements

Primary aldosteronism (PAs) is more strongly associated with cardiovascular complications and organ damage. Furthermore, approximately 10% of patients diagnosed with essential hypertension also have PA. We and others recently reported a very high frequency of somatic mutations in the KCNJ5 gene in PAs, but the detailed mechanism has not been evaluated. Therefore, we created a KCNJ5 mutant mouse model, and started to evaluate the onset mechanism of primary aldosteronism. The mutant KCNJ5 mice have not been found to have adrenal hyperplasia or tumorigenesis, but over expression of aldosterone synthetase was confirmed. In the future, we will continue to study in more detail and aim for the application to diagnosis and treatment of primary aldosteronism.

Free Research Field

内分泌学

Academic Significance and Societal Importance of the Research Achievements

原発性アルドステロン症の原因遺伝子としてKCNJ5変異が発見されたが、その臨床応用が可能となるような病態解明はほとんどされていない。今回我々が作成した疾患モデルの詳細な検討により、将来の診断や治療への応用が期待できる。