Regulation mechanism of Ras signal by novel RasGAP specific to blood cells

2019 Fiscal Year Annual Research Report

• Project/Area Number: 16K09822
• Research Institution: Niigata University
• Principal Investigator: 齋藤 孔良 新潟大学, 医歯学系, 助教 (30460356)
• Co-Investigator(Kenkyū-buntansha): 藤井 雅寛 新潟大学, 医歯学系, 教授 (30183099)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: RASAL3 / 遺伝子プロファイル

Outline of Annual Research Achievements

当該年度は、これまでに得られたデータの統計解析と論文化に注力した。RASAL3ノックアウトマウスおよび親系統のマウスの遺伝子発現をプロファイルしたマイクロアレイデータからRASAL3の発現と有意に相関する遺伝子を多数特定した。これらのRASAL3関連遺伝子のデータを含め、これまでの研究成果を論文にまとめる作業を行った。

Research Products

• [Journal Article] G3BP1 inhibits ubiquitinated protein aggregations induced by p62 and USP10. (2019)
  • Author(s): Anisimov S, Takahashi M, Kakihana T, Katsuragi Y, Kitaura H, Zhang L, Kakita A, Fujii M.
  • Journal Title: Scientific Reports Volume: 9 Pages: 3941
  • DOI: 10.1038/s41598-019-46237-1.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] USP10 Is a Critical Factor for Tau-positive Stress Granule Formation in Neuronal Cells (2019)
  • Author(s): Piatnitskaia S, Takahashi M, Kitaura H, Katsuragi Y, Kakihana T, Zhang L, Kakita A, Iwakura Y, Nawa H, Miura T, Ikeuchi T, Hara T, Fujii M.
  • Journal Title: Scientific Reports Volume: 9 Pages: 10591
  • DOI: 10.1038/s41598-019-47033-7.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The regulation of NDRG2 expression during ATLL development after HTLV-1 infection. (2019)
  • Author(s): Ichikawa T, Nakahata S, Fujii M, Iha H, Shimoda K, Morishita K.
  • Journal Title: Biochim Biophys Acta, Mol Basis Disease Volume: 1865 Pages: 2633-2646
  • DOI: 10.1016/j.bbadis.2019.07.001. Epub 2019 Jul 8.
  • Peer Reviewed / Open Access
• [Journal Article] Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB (2019)
  • Author(s): Sarkar B, Nishikata I, Nakahata S, Ichikawa T, Shiraga T, Saha HR, Fujii M, Tanaka Y, Shimoda K, Morishita K.
  • Journal Title: Scientific Reports Volume: 9 Pages: 3491
  • DOI: 10.1038/s41598-019-39424-7
  • Peer Reviewed / Open Access / Int'l Joint Research