Involvement of biotin metabolism in airway inflammation

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K09958
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Tohoku University
• Principal Investigator: Sakurai Mika 東北大学, 東北メディカル・メガバンク機構, 准教授 (80508359)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: ビオチン / 花粉症

Outline of Final Research Achievements

Biotin is a water-soluble B complex vitamin and play a role as a coenzyme of 5 carboxylases in mammals. It is well known that nutritional biotin deficiency causes eczema-like dermatitis. However, Molecular mechanism of this condition has not been studied well. Here, we investigated the role of biotin in the induction of inflammatory cytokines, chemokines, and MMPs by using mouse and cultured cell models of allergic inflammation. We found that the biotin deficiency in mice had a tendency to induce IgE secretion and inflammatory response without any stimulation. The molecular mechanism of this phenomenon warrants further investigation.

Free Research Field

分子生物学

Academic Significance and Societal Importance of the Research Achievements

本研究はビタミン学におけるビオチンの新たな生理的意義に加え、アレルギー性炎症におけるビオチン代謝の意義を示唆した。有病率の高いアレルギー性疾患について、ビオチンの関与をさらに分子レベルで解明することにより、将来的に、サプリメントやビオチン療法として取り入れることによりその症状改善の可能性が期待される。