2019 Fiscal Year Final Research Report
Elucidation of the pathogenesis of severe interstitial lung injury by analysis of MDA5 and anti-MDA5 antibodies
| Project/Area Number |
16K10022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Keywords | MDA5 / 若年性皮膚筋炎 / I型インターフェロン / 抗MDA5抗体 / 間質性肺炎 / インターフェロノパチー |
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| Outline of Final Research Achievements |
MDA5 is a cytoplasmic receptor that recognizes viral RNA and induces type I interferon (IFN)-based immunity. Autoantibodies against MDA5 are found in juvenile dermatomyositis with interstitial pneumonia, but serum MDA5 has not been investigated. In this study, soluble MDA5 was confirmed in serum in some patients with juvenile dermatomyositis and systemic lupus erythematosus by ELISA. MDA5 and IFNα increased in the same cases, suggesting that serum MDA5 may be involved in the pathophysiology of dermatomyositis, type I IFN is thought to play an important role in pathology.
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| Free Research Field |
小児科学、リウマチ・膠原病
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、若年性皮膚筋炎や全身性エリテマトーデス患者において、血液中のMDA5をELISAにより検出した。MDA5は、それらの疾患の病態に重要な役割を果たしていると考えられているI型IFNと関連している可能性が示唆された。これらの結果は、疾患の診断や病勢の評価への応用や病態解明を通して新たな治療法の開発につながる可能性がある。ただし、症例数が限られており、今後の検討が必要である
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