Analysis and development of a pinpointed and novel treatment focused on basophils for untreated skin allergic diseases

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K10124
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: YOKOZEKI Hiroo 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (90210608)
• Research Collaborator: Ugajin Tsukasa
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: basophil / prurigo / food allergy / contact dermatitis / atopic dermatitis / stat6 / Zn / anti-IgE antibody

Outline of Final Research Achievements

Prurigo nodularis, prurigo type atopic dermatitis is a chronic and untreated diseases. In order to investigate a mechanism for prurigo reaction, we have been established a murine model of prurigo by using a TNP-IgE transgenic mice (Immunity, 2005, Mukai K, J Immunol,2015, Hasimoto T et al). We investigated the mechanism of prurigo and that basophils are indispensable for prurigo-like inflammation, Th2 immunity mediated by STAT6 appears to play a protective role, and therapies targeting Th2-type cytokines may risk aggravating the inflammation. And we have established a murine model of food allergy caused by cutaneous immunization. We demonstrated that both basophils and mast cells play an important roles in the induction of this model mouse (Yu R eta l:Exp Dermatol, 2017;26(9):778-784.)

Free Research Field

皮膚科学

Academic Significance and Societal Importance of the Research Achievements

難治性慢性痒疹は、著明な痒みを主訴として比較的孤立性の強い丘疹が見られる疾患中高齢者に多い難治性疾患である。アトピー性皮膚炎の皮膚病変においても痒疹結節が重症成人型アトピー性皮膚炎で認められることが多く非常に難治性である。
我々の研究室では抗原特異的IgE遺伝子を導入したトランスジェニックマウスに大量抗原を同一の部位で惹起することにより痒疹モデルマウスを樹立して痒疹の発症機序を解析し、新規治療法の開発を試みた。